2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Cytotoxin
  5. Maytansinoids Isoform

Maytansinoids

Maytansinoids (DMs) interfere with microtubule assembly but are mechanistically similar to vinca alkaloids. Maytansines take effect by binding and capping the ‘plus’ end of the growing microtubule and block the polymerization of tubulin dimers preventing the formation of mature microtubules, causing mitotic arrest. Of the two DMs, DM1 and DM4 are widely used as ADC payloads.

Maytansinoids Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-19792
    Mertansine
    		99.80%
    Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).
  • HY-15739
    Ansamitocin P-3
    		≥98.0%
    Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.
  • HY-100128
    DM1-SMe
    		98.16%
    DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is about 3-10-fold more potent than the parent agent Maytansine, with IC50s ranging from 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
  • HY-130080
    DM3
    DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).
  • HY-130082
    DM4-SMe
    		98.02%
    DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM.
  • HY-100503
    Maytansinoid DM4
    Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC.
  • HY-126663
    N-Me-L-Ala-maytansinol
    		99.89%
    N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC).
  • HY-100504
    S-methyl DM1
    		99.58%
    S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects.
  • HY-130081
    DM3-SMe
    DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM.