MPC-0767 

MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester proagent of MPC-3100 with improved chemical stability^[1].

MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the T_max, C_max, AUC and F% are 1 (h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively^[1].
MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals^[1].
MPC-0767 is well tolerated when administered at 252 mg/kg po (equivalent to 200 mg/kg dose of MPC-3100)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

734.64

C₂₆H₃₆BrN₇O₉S₂

1310540-32-9

N[C@@H](C)C(O[C@@H](C)C(N1CCC(CCN2C(SC3=C(Br)C=C(OCO4)C4=C3)=NC5=C(N)N=CN=C25)CC1)=O)=O.CS(=O)(O)=O.[H]O[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Se-Ho Kim, et al. Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5254-7.  [Content Brief]