2. Apoptosis
  3. Apoptosis
  4. Neoechinulin A

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice.

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Neoechinulin A Chemical Structure

Neoechinulin A Chemical Structure

CAS No. : 51551-29-2

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Based on 1 publication(s) in Google Scholar

Neoechinulin A Related Antibodies

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Description

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].

Cellular Effect
Cell Line Type Value Description References
Huh7.5.1 CC50
> 20 μM
Compound: 7
Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
[PMID: 34967639]
MDCK CC50
> 200 μM
Compound: 17
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
[PMID: 25681711]
Vero C1008 CC50
> 100 μM
Compound: 7
Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
[PMID: 34967639]
In Vitro

Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2].
Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2].
Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neoechinulin A Related Antibodies
In Vivo

In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

323.39

Formula

C19H21N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CC(C)(C)C1=C(C2=CC=CC=C2N1)/C=C3C(N[C@H](C(N/3)=O)C)=O
Structure Classification
Initial Source

fungus Aspergillus sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (258 KB)

Handling Instructions (2659 KB)
References
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Neoechinulin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neoechinulin A51551-29-2Apoptosisalkaloidmemoryimprovementsantidepressantinflammationpro-inflammatoryRAW264.7macrophagesInhibitorinhibitorinhibit

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