2. Reference Standards
  3. Natural Product Standards
  4. Alkaloids

Alkaloids

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. They are classified on the basis of the principal C-N skeleton structure which includes numerous subclasses of alkaloids namely, pyrrole, pyridine, quinoline, isoquinoline, indole and other alkaloids, etc. Alkaloids have a wide range of pharmacological activities including antimalarial, anti-asthmatic, anti-cancer, cholinomimetic, vasodilating, anti-arrhythmic, analgesic, anti-bacterial, and anti-diabetic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. They possess potent pharmacological effects for eg. the well-known plant alkaloids include the narcotic analgesics, morphine and codeine, the muscle relaxant papaverine, and the antimicrobial agents sanguinarine and berberine. And some alkaloids are toxic.

Alkaloids (298):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0623R
    L-Tryptophan (standard) 73-22-3 ≥98%
    L-Tryptophan (standard) is the analytical standard of L-Tryptophan. L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels.
    L-Tryptophan (standard)
  • HY-100807R
    Quinolinic acid (Standard) 89-00-9 99.96%
    Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
    Quinolinic acid (Standard)
  • HY-B0150R
    Nicotinamide (Standard) 98-92-0 99.85%
    Nicotinamide (Standard) is the analytical standard of Nicotinamide. This product is intended for research and analytical applications. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
    Nicotinamide (Standard)
  • HY-B2176R
    ATP (Standard) 56-65-5 ≥98%
    ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
    ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
    ATP promotes neutrophil chemotaxis in vitro.
    In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
    ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.
    ATP (Standard)
  • HY-100806R
    Kynurenic acid (Standard) 492-27-3 ≥98%
    Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
    Kynurenic acid (Standard)
  • HY-107383R
    Tetrahydrobiopterin (Standard) 17528-72-2 ≥98%
    Tetrahydrobiopterin (Standard) is the analytical standard of Tetrahydrobiopterin. This product is intended for research and analytical applications. Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.
    Tetrahydrobiopterin (Standard)
  • HY-W001132R
    Indole (standard) 120-72-9 ≥98%
    Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule.
    Indole (standard)
  • HY-13715AR
    Norepinephrine (hydrochloride) (Standard) 329-56-6 ≥98%
    Norepinephrine (hydrochloride) (Standard)
  • HY-B0809R
    Theophylline (Standard) 58-55-9 99.99%
    Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
    Theophylline (Standard)
  • HY-104026R
    L-Kynurenine (Standard) 2922-83-0 ≥98%
    L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
    L-Kynurenine (Standard)
  • HY-B1716R
    L-5-Hydroxytryptophan (Standard) 4350-09-8 ≥98%
    L-5-Hydroxytryptophan (Standard) is the analytical standard of L-5-Hydroxytryptophan. This product is intended for research and analytical applications. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.
    L-5-Hydroxytryptophan (Standard)
  • HY-13738AR
    Raloxifene (hydrochloride) (Standard) 82640-04-8 99.84%
    Raloxifene (hydrochloride) (Standard) is the analytical standard of Raloxifene (hydrochloride). This product is intended for research and analytical applications. Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.
    Raloxifene (hydrochloride) (Standard)
  • HY-N0488R
    Vincristine (sulfate) (Standard) 2068-78-2 ≥98%
    Vincristine (sulfate) (Standard) is the analytical standard of Vincristine (sulfate). This product is intended for research and analytical applications. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
    Vincristine (sulfate) (Standard)
  • HY-N0737AR
    Harmine (Standard) 442-51-3 ≥98%
    Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.
    Harmine (Standard)
  • HY-W342604R
    N-Acetylputrescine (Standard) 5699-41-2 ≥98%
    1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production.
    N-Acetylputrescine (Standard)
  • HY-113081R
    1-Methyladenosine (Standard) 15763-06-1 ≥98%
    1-Methyladenosine (Standard) is the analytical standard of 1-Methyladenosine. This product is intended for research and analytical applications. 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis. In Vitro:Compared to surrounding tumor tissues, 1-methyladenosine methylation in RNA is aberrantly elevated in hepatocellular carcinoma (HCC) cell lines and liver cancer stem cells (CSCs). Methylated 1-methyladenosine can promote cholesterol synthesis and activate the Hedgehog signaling pathway by enhancing the translation of PPARδ in liver CSCs, ultimately driving the self-renewal and tumorigenesis of liver cancer stem cells.
    1-Methyladenosine (Standard)
  • HY-N0738R
    Stachydrine hydrochloride (Standard) 4136-37-2 ≥98%
    Stachydrine hydrochloride (Standard) is the analytical standard of Stachydrine hydrochloride. This product is intended for research and analytical applications. Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.
    Stachydrine hydrochloride (Standard)
  • HY-113382R
    N-Methylhydantoin (Standard) 616-04-6 ≥98%
    Delphinidin 3-glucoside (chloride) (Standard) is the analytical standard of Delphinidin 3-glucoside (chloride). This product is intended for research and analytical applications. Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.
    N-Methylhydantoin (Standard)
  • HY-Y1129R
    3-Hydroxypyridine (Standard) 109-00-2 ≥98%
    3-Hydroxypyridine (Standard)
  • HY-N0049R
    Nuciferine (Standard) 475-83-2 ≥98%
    Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
    Nuciferine (Standard)