Norepinephrine tartrate (Synonyms: Levarterenol tartrate; L-Noradrenaline tartrate)

Cat. No.: HY-13715C: FAQs
Data Sheet Handling Instructions

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Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors.

For research use only. We do not sell to patients.

Norepinephrine tartrate Chemical Structure

CAS No. : 51-40-1

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Other Forms of Norepinephrine tartrate:

Norepinephrine In-stock
Norepinephrine hydrochloride In-stock
Norepinephrine bitartrate monohydrate In-stock

27 Publications Citing Use of MCE Norepinephrine tartrate

: Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311. [Abstract]; Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

: Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118. [Abstract]; PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]

α1-adrenergic receptor

α2-adrenergic receptor

Beta-1 adrenergic receptor

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β₁-subtype selective adrenergic agonist over β₂-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β₂-adrenoceptor in higher concentrations^[2].
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:	Subcutaneous preadipocytes Adipocytes.
Concentration:	10 μM.
Incubation Time:	6 hours.
Result:	AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)

In Vivo

Induction of cardiomyopathy^[5]^[6]

Background

Norepinephrine is a potent growth factor for cardiomyocytes, and long-term infusion of sub-hypertensive doses of Norepinephrine in animals can cause an increase in myocardial mass and left ventricular wall thickness. Norepinephrine activates the raf-1 kinase/MAP kinase cascade through α1 and β-adrenergic stimulation, and the signaling pathways from these two receptors work synergistically to induce cardiomyocyte hypertrophy.

Specific Modeling Methods

Rat: Spragues-Dawley rats • adult (6 months old) • Male &bull.
Administration: Each rat was continuously injected with 100 μg/kg/h (Norepinephrine; HY-13715) or 200 μg/kg/h (Norepinephrine; HY-13715) through an osmotic minipump.

Note

Modeling Indicators

Molecular changes: Significantly increased Dnmt activity and the expressions of Dnmt1, 3a, and 3b in the left ventricle.
Significantly increased the mRNA expressions of fetal genes ANP, BNP, and βMHC in the left ventricle.
Significantly increased ROS production in the left ventricle and increased global genomic DNA methylation and gene-specific CpG methylation at the Egr-1 binding site of the left ventricular PKCε promoter region in a concentration-dependent manner.
Increased lactate dehydrogenase release in a concentration-dependent manner.
Significantly reduced the left ventricular developed pressure and dP/dtmax, inducing the upregulation of myotrophin and downregulation of four-and-a-half LIM domains protein 2 (FHL2).
Phenotype observations: Increased the myocardial infarction area and sustained the elevation of blood pressure.
Induced cardiac hypertrophy and reduced cardiac contractility.
Increased the left ventricular weight.

Correlated Product(s)

Opposite Product(s) 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

319.26

Formula

C₁₂H₁₇NO₉

CAS No.

51-40-1

SMILES

OC1=CC=C([C@@H](O)CN)C=C1O.OC([C@H](O)[C@@H](O)C(O)=O)=O

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36. [Content Brief]

[2]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [Content Brief]

[3]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. [Content Brief]

[4]. Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579. [Content Brief]

Norepinephrine tartrate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norepinephrine51-40-1LevarterenolL-NoradrenalineEndogenous MetaboliteAdrenergic ReceptorAutophagyBeta Receptoradrenergic receptorα1α2β1Inhibitorinhibitorinhibit

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