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  5. Norepinephrine tartrate

Norepinephrine tartrate  (Synonyms: Levarterenol tartrate; L-Noradrenaline tartrate)

Cat. No.: HY-13715C Purity: 99.45%
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Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors.

For research use only. We do not sell to patients.

Norepinephrine tartrate Chemical Structure

Norepinephrine tartrate Chemical Structure

CAS No. : 51-40-1

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Based on 39 publication(s) in Google Scholar

Other Forms of Norepinephrine tartrate:

Norepinephrine tartrate Related Antibodies

Top Publications Citing Use of Products

37 Publications Citing Use of MCE Norepinephrine tartrate

IF
WB

    Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.  [Abstract]

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.  [Abstract]

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

    View All Adrenergic Receptor Isoform Specific Products:

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    α adrenergic receptor β adrenergic receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors[1][2][3][4].

    IC50 & Target[1]

    α1-adrenergic receptor

     

    α2-adrenergic receptor

     

    Beta-1 adrenergic receptor

     

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO EC50
    1019 nM
    Compound: noradrenaline
    Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
    Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
    		[PMID: 26087939]
    In Vitro

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
    Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
    Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
    Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Norepinephrine tartrate Related Antibodies

    RT-PCR[2]

    Cell Line: Subcutaneous preadipocytes Adipocytes.
    Concentration: 10 μM.
    Incubation Time: 6 hours.
    Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)
    In Vivo

    Induction of cardiomyopathy[5][6]

    Background
    Norepinephrine is a potent growth factor for cardiomyocytes, and long-term infusion of sub-hypertensive doses of Norepinephrine in animals can cause an increase in myocardial mass and left ventricular wall thickness. Norepinephrine activates the raf-1 kinase/MAP kinase cascade through α1 and β-adrenergic stimulation, and the signaling pathways from these two receptors work synergistically to induce cardiomyocyte hypertrophy.
    Specific Mmodeling Methods
    Rat: Spragues-Dawley rats • adult (6 months old) • Male &bull.
    Administration: Each rat was continuously injected with 100 μg/kg/h (Norepinephrine; HY-13715) or 200 μg/kg/h (Norepinephrine; HY-13715) through an osmotic minipump.
    Note
    Modeling Record
    Molecular changes: Significantly increased Dnmt activity and the expressions of Dnmt1, 3a, and 3b in the left ventricle.
    Significantly increased the mRNA expressions of fetal genes ANP, BNP, and βMHC in the left ventricle.
    Significantly increased ROS production in the left ventricle and increased global genomic DNA methylation and gene-specific CpG methylation at the Egr-1 binding site of the left ventricular PKCε promoter region in a concentration-dependent manner.
    Increased lactate dehydrogenase release in a concentration-dependent manner.
    Significantly reduced the left ventricular developed pressure and dP/dtmax, inducing the upregulation of myotrophin and downregulation of four-and-a-half LIM domains protein 2 (FHL2).
    Phenotype observations: Increased the myocardial infarction area and sustained the elevation of blood pressure.
    Induced cardiac hypertrophy and reduced cardiac contractility.
    Increased the left ventricular weight.
    Correlated Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    319.26

    Formula

    C12H17NO9
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=CC=C([C@@H](O)CN)C=C1O.OC([C@H](O)[C@@H](O)C(O)=O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (313.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1322 mL 15.6612 mL 31.3224 mL
    5 mM 0.6264 mL 3.1322 mL 6.2645 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1322 mL 15.6612 mL 31.3224 mL 78.3061 mL
    5 mM 0.6264 mL 3.1322 mL 6.2645 mL 15.6612 mL
    10 mM 0.3132 mL 1.5661 mL 3.1322 mL 7.8306 mL
    15 mM 0.2088 mL 1.0441 mL 2.0882 mL 5.2204 mL
    20 mM 0.1566 mL 0.7831 mL 1.5661 mL 3.9153 mL
    25 mM 0.1253 mL 0.6264 mL 1.2529 mL 3.1322 mL
    30 mM 0.1044 mL 0.5220 mL 1.0441 mL 2.6102 mL
    40 mM 0.0783 mL 0.3915 mL 0.7831 mL 1.9577 mL
    50 mM 0.0626 mL 0.3132 mL 0.6264 mL 1.5661 mL
    60 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3051 mL
    80 mM 0.0392 mL 0.1958 mL 0.3915 mL 0.9788 mL
    100 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.7831 mL
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    Norepinephrine tartrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Norepinephrine51-40-1LevarterenolL-NoradrenalineEndogenous MetaboliteAdrenergic ReceptorAutophagyBeta Receptoradrenergic receptorα1α2β1Inhibitorinhibitorinhibit

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