2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. PPA

PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate.

For research use only. We do not sell to patients.

PPA Chemical Structure

PPA Chemical Structure

CAS No. : 452072-22-9

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Based on 1 publication(s) in Google Scholar

PPA Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

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Description

PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate[1].

IC50 & Target

Disulfide Cleavable Linker

 

Clinical Trial
Molecular Weight

243.35

Formula

C10H13NO2S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(SSC1=NC=CC=C1)CCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (410.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1093 mL 20.5463 mL 41.0926 mL
5 mM 0.8219 mL 4.1093 mL 8.2185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1093 mL 20.5463 mL 41.0926 mL 102.7314 mL
5 mM 0.8219 mL 4.1093 mL 8.2185 mL 20.5463 mL
10 mM 0.4109 mL 2.0546 mL 4.1093 mL 10.2731 mL
15 mM 0.2740 mL 1.3698 mL 2.7395 mL 6.8488 mL
20 mM 0.2055 mL 1.0273 mL 2.0546 mL 5.1366 mL
25 mM 0.1644 mL 0.8219 mL 1.6437 mL 4.1093 mL
30 mM 0.1370 mL 0.6849 mL 1.3698 mL 3.4244 mL
40 mM 0.1027 mL 0.5137 mL 1.0273 mL 2.5683 mL
50 mM 0.0822 mL 0.4109 mL 0.8219 mL 2.0546 mL
60 mM 0.0685 mL 0.3424 mL 0.6849 mL 1.7122 mL
80 mM 0.0514 mL 0.2568 mL 0.5137 mL 1.2841 mL
100 mM 0.0411 mL 0.2055 mL 0.4109 mL 1.0273 mL
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PPA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPA452072-22-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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