2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Rivenprost

Rivenprost  (Synonyms: ONO-4819; ONO-AE1-734)

Cat. No.: HY-114974 Purity: ≥99.0%
SDS COA Handling Instructions Technical Support

Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects.

For research use only. We do not sell to patients.

Rivenprost Chemical Structure

Rivenprost Chemical Structure

CAS No. : 256382-08-8

Size Price Stock Quantity
Solvent
100 μg (2.22 mM * 100 μL in Methyl acetate) In-stock
Solvent
500 μg (2.22 mM * 500 μL in Methyl acetate) In-stock
Solvent
1 mg (2.22 mM * 1 mL in Methyl acetate) In-stock
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Based on 1 publication(s) in Google Scholar

Rivenprost Related Antibodies

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Description

Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].

IC50 & Target

EP4

0.7 nM (Ki)

In Vitro

Rivenprost (1 nM–1 μM) stimulates the osteoblast differentiation through upregulation of Runx2 and Osterix, leading to increased bone formation[1].
Rivenprost (1 nM–1 μM) inhibits the adipocytes differentation in bone by downregulating the mRNA expression of PPARγ[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rivenprost Related Antibodies

RT-PCR[1]

Cell Line: C3H10T1/2
Concentration: 1 nM–1 μM
Incubation Time: 7 days
Result: Reduced PPARγ in a dose-dependent manner.
In Vivo

Rivenprost (10 μg/kg, s.c. for 5 weeks) increases bone formation and decreases levels of age-dependent adipocytes in Sprague-Dawley rats[1].
Rivenprost (0.2 mg/kg, i.p., single dosage) exhibits hepatoprotective efficacy towards GalN-/LPS-induced liver injury in wistar rats through inflammatory cytokines such as TNF-α[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[1]
Dosage: 10 μg/kg
Administration: s.c., twice a day for 5 weeks
Result: Increased osteoblast number, bone volume, mineral apposition rate and bone formation rate.
Decreased adipocyte number.
Animal Model: GalN/LPS-induced acute liver injury in wistar rats[2]
Dosage: 0.2 mg/kg
Administration: i.p., single dosage
Result: Inhibited development of hepatic necrosis, decreased levels of AST, ALT, TNF-α and IFN-γ.
Molecular Weight

450.59

Formula

C24H34O6S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCC1=CC=CC(C[C@H](O)/C=C/[C@@H]2[C@H](C(C[C@H]2O)=O)CCSCCCC(OC)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References
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Rivenprost Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rivenprost256382-08-8ONO-4819 ONO-AE1-734ONO4819ONO 4819Prostaglandin ReceptorC3H10T1/2hepatoprotectiveInhibitorinhibitorinhibit

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