(Sar1)-Angiotensin II

Name: (Sar1)-Angiotensin II
Brand: MedChemExpress
SKU: HY-P3138
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3138 Purity: 99.84%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a K_d of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

(Sar1)-Angiotensin II Chemical Structure

CAS No. : 51833-69-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

AT1 Receptor

In Vitro

(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively^[2].
(Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a K_d of 2.7 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1002.17

Formula

C₄₉H₇₁N₁₃O₁₀

CAS No.

51833-69-3

Appearance

Solid

Color

White to off-white

Sequence Shortening

{Sar}-RVYIHPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (99.78 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9978 mL	4.9892 mL	9.9783 mL
5 mM	0.1996 mL	0.9978 mL	1.9957 mL
10 mM	0.0998 mL	0.4989 mL	0.9978 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (109 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38(23):4660-9. [Content Brief]

[2]. Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258(3 Pt 2):H806-13. [Content Brief]

[3]. Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11(2):243-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.9978 mL	4.9892 mL	9.9783 mL	24.9459 mL
	5 mM	0.1996 mL	0.9978 mL	1.9957 mL	4.9892 mL
	10 mM	0.0998 mL	0.4989 mL	0.9978 mL	2.4946 mL
	15 mM	0.0665 mL	0.3326 mL	0.6652 mL	1.6631 mL
	20 mM	0.0499 mL	0.2495 mL	0.4989 mL	1.2473 mL
	25 mM	0.0399 mL	0.1996 mL	0.3991 mL	0.9978 mL
	30 mM	0.0333 mL	0.1663 mL	0.3326 mL	0.8315 mL
	40 mM	0.0249 mL	0.1247 mL	0.2495 mL	0.6236 mL
	50 mM	0.0200 mL	0.0998 mL	0.1996 mL	0.4989 mL
	60 mM	0.0166 mL	0.0832 mL	0.1663 mL	0.4158 mL
	80 mM	0.0125 mL	0.0624 mL	0.1247 mL	0.3118 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.