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Bromine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (1) Bcl-2 Family (1) Biochemical Assay Reagents (3) DNA/RNA Synthesis (2) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (2) Epigenetic Reader Domain (7) Histone Acetyltransferase (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) NF-κB (1) Notch (1) p38 MAPK (2) PROTACs (3) Ras (1) α-synuclein (1)
By Research Areas:	Cancer (11) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124284

Hexamethylene bisacetamide HMBA	Apoptosis p38 MAPK Akt NF-κB Notch Bcl-2 Family MDM-2/p53 Epigenetic Reader Domain	Neurological Disease Metabolic Disease Cancer
Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice .

HY-163729

I-BET787	Epigenetic Reader Domain	Inflammation/Immunology
I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation .

HY-117690

dBRD9	PROTACs Epigenetic Reader Domain	Cancer
dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family .

HY-W021597

N-Boc-5-bromoindole	Drug Intermediate	Others
N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination .

HY-59299

3-Bromothiophene 3-Bromothiophene	Biochemical Assay Reagents	Others
3-Bromothiophene is a bromine atom-substituted 3-halogenated thiophene with electrochemical stability, small porosity, and high π-π* lowest transition energy. 3-Bromothiophene is often used as a conductive polymer monomer .

HY-169372

(S,R,S)-AHPC-CO-C4-bromine	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-CO-C4-bromine is an E3 Ligase Ligand-linker Conjugate for PROTAC synthesis. (S,R,S)-AHPC-CO-C4-bromine is composed of an E3 Ligase Ligand (HY-125845) and a linker

HY-169397

Thalidomide-NH-CH2-CONH-C2-PEG-bromine	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-CH2-CONH-C2-PEG-bromine is a conjugate of the E3 ligase ligand and the linker, that can be used for synthesis of PROTAC degrader SK-3-91 (HY-137341) .

HY-126965

Lipid Y	Others	Others
Lipid Y is a potent monosaccharide which contains two bromines per chain. lipid Y binds to a tryptophan residue in a membrane protein and then quenches the fluorescence of the tryptophan residue .

HY-148739

dBRD 9-A	PROTACs Epigenetic Reader Domain	Cancer
dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family .

HY-130398

Aerophobin-2	α-synuclein	Neurological Disease
Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy .

HY-162281

PROTAC SOS1 degrader-6	PROTACs Ras	Cancer
PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRAS ^G12C inhibitors . PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).

HY-160662

BRD4-IN-5	Epigenetic Reader Domain	Cancer
BRD4-IN-5 (example 51) is a BRD4 inhibitor. The K_i values of the two BRD4 domains BDI_K57-E168 and BDII_E352-M457 are 9.7 nM and 16.1 nM, respectively. BRD4-IN-5 can be used in cancer research .

HY-161711

CBP/p300 ligand 5	Ligands for Target Protein for PROTAC	Cancer
CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia .

HY-W076740

8-Bromoadenine 8-Bromo-9H-purin-6-amine	DNA/RNA Synthesis Biochemical Assay Reagents	Others
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .

HY-150239

BAY-364 BAY-299N	DNA/RNA Synthesis	Cancer
BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34 ⁺ cells and K562 cells with IC₅₀ values of 1.0 µM, 10.4 µM and 10.0 µM respectively .

HY-W011972

Bromocholine bromide	Biochemical Assay Reagents	Others
2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.

HY-136794

SB-284851-BT	p38 MAPK Epigenetic Reader Domain	Inflammation/Immunology Cancer
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC₅₀=1.7 µM), p38α (K_d=0.47 nM), BRDT (1) (IC₅₀=18 µM) and BRD4 (1)(IC₅₀=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET) .

HY-161483

CBP/p300 ligand 3	Epigenetic Reader Domain Histone Acetyltransferase	Neurological Disease Cancer
CBP/p300 ligand 3 is a target protein ligand of CBPD-268 (HY-161369). CBP and p300 are two proteins with histone acetyltransferase (HAT) activity, and CBP and p300 play key roles in regulating biological processes such as gene expression, cell proliferation, differentiation and DNA repair. Through its acetyltransferase activity, CBP/p300 can acetylate histones and other proteins, thereby regulating chromatin structure and gene expression. CBP/p300 ligand 3 regulates the function of CBP/p300 by binding to a specific domain of the CBP/p300 protein (the bromine domain or HAT domain), inhibiting its enzyme activity or altering its interactions with other proteins (transcription factors). CBP/p300 ligand 3 can be used in cancer, neurodegenerative diseases and other disease models associated with abnormal CBP/p300 function .

Cat. No.	Product Name	Type

HY-59299

3-Bromothiophene 3-Bromothiophene	Biochemical Assay Reagents
3-Bromothiophene is a bromine atom-substituted 3-halogenated thiophene with electrochemical stability, small porosity, and high π-π* lowest transition energy. 3-Bromothiophene is often used as a conductive polymer monomer .

HY-W076740

8-Bromoadenine 8-Bromo-9H-purin-6-amine	Gene Sequencing and Synthesis
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .

HY-W011972

Bromocholine bromide	Biochemical Assay Reagents
2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.

Bromocholine bromide

Biochemical Assay Reagents

2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.

Aerophobin-2	Structural Classification Natural Products Marine natural products Source classification Sponge	α-synuclein
Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy .

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Bromine

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products