2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. dBRD9

dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family.

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dBRD9 Chemical Structure

dBRD9 Chemical Structure

CAS No. : 2170679-45-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 552 In-stock
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1 mg USD 160 In-stock
5 mg USD 400 In-stock
10 mg USD 640 In-stock
25 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of dBRD9:

dBRD9 Related Antibodies

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Description

dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1].

IC50 & Target[1]

BRD9

 

In Vitro

dBRD9 (0.5-5000 nM; 4 h) reduces the expression of BRD9 with concentration-dependent manner, but has insignificant effect on the expression of actin, BRD4 and BRD7 in MOLM-13 cells[1].
dBRD9 (100 nM; 2 h) is selective for BRD9 in MOLM-13 cells[1].
dBRD9 (7 d) has anti-proliferation effect on EOL-1 and MOML-13 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

dBRD9 Related Antibodies

Western Blot Analysis[1]

Cell Line: MOLM-13 cells.
Concentration: 0.5, 5, 50, 500 and 5000 nM.
Incubation Time: 4 h.
Result: Reduced the expression of BRD9.
Molecular Weight

783.83

Formula

C40H45N7O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2758 mL 6.3789 mL 12.7579 mL
5 mM 0.2552 mL 1.2758 mL 2.5516 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2758 mL 6.3789 mL 12.7579 mL 31.8947 mL
5 mM 0.2552 mL 1.2758 mL 2.5516 mL 6.3789 mL
10 mM 0.1276 mL 0.6379 mL 1.2758 mL 3.1895 mL
15 mM 0.0851 mL 0.4253 mL 0.8505 mL 2.1263 mL
20 mM 0.0638 mL 0.3189 mL 0.6379 mL 1.5947 mL
25 mM 0.0510 mL 0.2552 mL 0.5103 mL 1.2758 mL
30 mM 0.0425 mL 0.2126 mL 0.4253 mL 1.0632 mL
40 mM 0.0319 mL 0.1595 mL 0.3189 mL 0.7974 mL
50 mM 0.0255 mL 0.1276 mL 0.2552 mL 0.6379 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5316 mL
80 mM 0.0159 mL 0.0797 mL 0.1595 mL 0.3987 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3189 mL
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dBRD9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dBRD92170679-45-3dBRD 9dBRD-9PROTACsEpigenetic Reader DomainEOL-1MOML-13BRD9Inhibitorinhibitorinhibit

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