8-Bromoadenine (Synonyms: 8-Bromo-9H-purin-6-amine)

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8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium.

For research use only. We do not sell to patients.

8-Bromoadenine Chemical Structure

CAS No. : 6974-78-3

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50 mg	USD 60	Ask For Quote & Lead Time
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Description	8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium^[1]^[2].
In Vitro	8-Bromoadenine (0.1 mM; 30-90 min) inhibits DNA single-strand break repair in HeLa-M cell monolayer cultures. And after γ irradiation, the quality of DNA synthesized by cells is lower than that of DNA synthesized by cells without purine addition^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 8-Bromoadenine Related Antibodies
Molecular Weight	214.02
Formula	C₅H₄BrN₅
CAS No.	6974-78-3
Appearance	Solid
SMILES	BrC1=NC2=C(N1)C(N)=NC=N2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22(8): 994-997. [2]. Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12.

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Bromoadenine6974-78-38-Bromo-9H-purin-6-amineBiochemical Assay ReagentsDNA/RNA SynthesisInhibitorinhibitorinhibit

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8-Bromoadenine (Synonyms: 8-Bromo-9H-purin-6-amine)

8-Bromoadenine Related Antibodies

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