N-Boc-5-bromoindole

Cat. No.: HY-W021597 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination.

For research use only. We do not sell to patients.

N-Boc-5-bromoindole Chemical Structure

CAS No. : 182344-70-3

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Free Sample (0.1 - 0.5 mg)	Apply Now
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination^[1].

Molecular Weight

296.16

Formula

C₁₃H₁₄BrNO₂

CAS No.

182344-70-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC(C)(C)C)N1C=CC2=C1C=CC(Br)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (675.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3765 mL	16.8825 mL	33.7651 mL
5 mM	0.6753 mL	3.3765 mL	6.7530 mL
10 mM	0.3377 mL	1.6883 mL	3.3765 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (252 KB) HNMR (134 KB) RP-HPLC (195 KB)

Handling Instructions (2659 KB)

References

[1]. Christoffer Bengtsson, et al. Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug. Molecules. 2023 Jun 16;28(12):4818. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3765 mL	16.8825 mL	33.7651 mL	84.4127 mL
	5 mM	0.6753 mL	3.3765 mL	6.7530 mL	16.8825 mL
	10 mM	0.3377 mL	1.6883 mL	3.3765 mL	8.4413 mL
	15 mM	0.2251 mL	1.1255 mL	2.2510 mL	5.6275 mL
	20 mM	0.1688 mL	0.8441 mL	1.6883 mL	4.2206 mL
	25 mM	0.1351 mL	0.6753 mL	1.3506 mL	3.3765 mL
	30 mM	0.1126 mL	0.5628 mL	1.1255 mL	2.8138 mL
	40 mM	0.0844 mL	0.4221 mL	0.8441 mL	2.1103 mL
	50 mM	0.0675 mL	0.3377 mL	0.6753 mL	1.6883 mL
	60 mM	0.0563 mL	0.2814 mL	0.5628 mL	1.4069 mL
	80 mM	0.0422 mL	0.2110 mL	0.4221 mL	1.0552 mL
	100 mM	0.0338 mL	0.1688 mL	0.3377 mL	0.8441 mL