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Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM .
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker compound extracted from patent WO2019195665A1, example 4-1. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC) .
MAD1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L1BP Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L1BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT is a agent-linker conjugate for antibody-drug conjugate (ADC). MP-PEG8-Val-Lys-Ala-7-MAD-MDCPT has the potential for cancer and autoimmune disease research.
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro .
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro .
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC) .
M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC) .
2-Thiobarbituric acid is a commonly used colorimetric reagent for the detection of malondialdehyde (MDA), a marker of lipid peroxidation. 2-Thiobarbituric acid forms a complex with MDA that can be quantified by colorimetric detection at 532 nm as a measure of lipid peroxidation .
OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes .
2-Thiobarbituric acid is a commonly used colorimetric reagent for the detection of malondialdehyde (MDA), a marker of lipid peroxidation. 2-Thiobarbituric acid forms a complex with MDA that can be quantified by colorimetric detection at 532 nm as a measure of lipid peroxidation .
SMAD2 protein, an R-SMAD, acts as a transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds TRE elements, regulating TGF-beta target genes. Forming a complex with SMAD4, it promotes transcription, positively regulating PDPK1 and showing potential tumor suppressor functions in colorectal carcinoma. SMAD2 interacts with various proteins, participating in signal transduction and transcriptional regulation. SMAD2 Protein, Human (His-SUMO) is the recombinant human-derived SMAD2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
MAD2L1 is a critical spindle assembly checkpoint component that delays anaphase until correct chromosome alignment. During prophase, it forms a heterotetrameric complex with MAD1L1 at unattached kinetochores, recruiting O-MAD2 and aiding transformation. MAD2L1 Protein, Human (His-SUMO) is the recombinant human-derived MAD2L1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
The SMAD3 protein acts as a receptor-regulated SMAD (R-SMAD), transducing signals from TGF-β and activin type 1 receptor kinase. After being activated by antigen-presenting cells, SMAD3 binds to the TRE element in the gene promoter and forms a complex with SMAD4 to activate transcription. SMAD3 Protein, Human (Flag-His) is the recombinant human-derived SMAD3 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.
SMAD4 is a class of common mediator SMAD (Co-SMAD), which belongs to the dwarfin/SMAD family. It conducts cell signals through the SMAD4/TGF-β pathway and plays an important role in promoting bone development and tissue homeostasis. SMAD4 induces chondrogenesis of human bone marrow mesenchymal stem cells, and specifically targets stem cells to participate in self-renewal of hematopoietic stem cells. SMAD4 can also protect cell apoptosis and inhibit epithelial cell proliferation, showing antitumor effects. SMAD4 Protein, Human (His) has the 552 a.a. sequence (M1-D552), produced in E.coli with C-terminal 6*His-tag.
SMAD2 protein interacts with multiple partners, such as CREB-binding protein (CBP), EP300, SNON, and others.These interactions contribute to diverse cellular processes, including TGF-beta signaling and transcriptional regulation.SMAD2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived SMAD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
WB, IHC-P, IP
Human, Mouse, Rat
IKB alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to IKB alpha. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.
NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
WB
Human, Mouse
Phospho-IKB alpha (Ser36) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser36). It can be used for WB assays with tag free, in the background of Human, Mouse.
NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
WB, IP
Human, Mouse
Phospho-IKB alpha (Ser32) Antibody (YA185) is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser32). It can be used for WB,IP assays with tag free, in the background of Human, Mouse.
SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; MAD3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; SMAD3; hSMAD3
WB, IHC-P, ICC/IF
Human, Mouse
Phospho-Smad3 (Ser423/425) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 48 kDa, targeting to Phospho-Smad3 (Ser423/425). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.
MAD2L1BP; CMT2; KIAA0110; MAD2L1-binding protein; Caught by MAD2 protein
WB, IHC-P, ICC/IF
Human, Mouse, Rat
MAD2L1 Binding Protein Antibody (YA3063) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3063), targeting MAD2L1 Binding Protein, with a predicted molecular weight of 31 kDa (observed band size: 34 kDa). MAD2L1 Binding Protein Antibody (YA3063) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
MAD2L1; MAD2; Mitotic spindle assembly checkpoint protein MAD2A; HsMAD2; Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1
WB
Human
MAD2L1 Antibody (YA1692) is a biotin-conjugated non-conjugated IgG antibody, targeting MAD2L1, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). MAD2L1 Antibody (YA1692) can be used for WB experiment in human background.
MAD2L2 Antibody (YA3190) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3190), targeting MAD2L2, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). MAD2L2 Antibody (YA3190) can be used for WB, ICC/IF, IP experiment in human background.
MAD1L1 Antibody (YA2449) is a biotin-conjugated non-conjugated IgG antibody, targeting MAD1L1, with a predicted molecular weight of 83 kDa (observed band size: 80 kDa). MAD1L1 Antibody (YA2449) can be used for WB experiment in human, mouse, rat background.
BUB1B; BUBR1; MAD3L; SSK1; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1
WB, ICC/IF, IP
Human
BUBR1 Antibody (YA2757) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2757), targeting BUBR1, with a predicted molecular weight of 120 kDa (observed band size: 120 kDa). BUBR1 Antibody (YA2757) can be used for WB, ICC/IF, IP experiment in human background.
MAD (mothers against decapentaplegic Drosophila) homolog 7; MAD; MAD homolog 7; MAD mothers against decapentaplegic homolog 7; MADH 7; MADH 8; MADH8; Mothers Against Decapentaplegic Drosophila Homolog of 7; Mothers against decapentaplegic homolog 7; Mothers against decapentaplegic homolog 8; Mothers against DPP homolog 7; Mothers against DPP homolog 8; SMA- AND MAD-RELATED PROTEIN 7; SMAD 7; SMAD; SMAD family member 7; SMAD, mothers against DPP homolog 7 (Drosophila); SMAD, mothers against DPP homolog 7; SMAD7_HUMAN.
WB, ELISA, IHC-P, IHC-F, FC, ICC/IF,
Human, Mouse, Rat
SMAD7 Antibody is an unconjugated, approximately 46 kDa, rabbit-derived, anti-SMAD7 polyclonal antibody. SMAD7 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: pig, cow background without labeling.
DKFZp781C1895; DKFZp781O1323; Dwfc; hSMAD 5; hSMAD5; JV5 1; JV5-1; MAD homolog 5; MAD mothers against decapentaplegic homolog 5; MAD; mothers against decapentaplegic homolog 5; MADH 5; MADH5; Mothers against decapentaplegic homolog 5; Mothers against DPP homolog 5; MusMLP; SMA and MAD related protein 5; SMAD 5; SMAD family member 5; SMAD mothers against DPP homolog 5; SMAD5; SMAD5; SMAD5_HUMAN.
WB, IHC-P, ICC/IF
Human, Mouse, Rat
Phospho-Smad5 (Ser463/465) Antibody (YA2838) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2838), targeting Phospho-Smad5 (Ser463/465), with a predicted molecular weight of 52 kDa (observed band size: 58 kDa). Phospho-Smad5 (Ser463/465) Antibody (YA2838) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; MAD-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; SMAD2; hSMAD2
WB, ICC/IF, FC, IP, ChIP
Human, Mouse, Rat
Smad2/3 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 52 kDa, targeting to Smad2/3. It can be used for WB,ICC/IF,FC,IP,ChIP assays with tag free, in the background of Human, Mouse, Rat.
SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; MAD-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; SMAD2; hSMAD2
WB
Human, Mouse, Rat, Hamster
Phospho-Smad2 (Ser250) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Phospho-Smad2 (Ser250). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Hamster.
SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; MAD-related protein 1; SMAD family member 1; SMAD 1; SMAD1; hSMAD1; Transforming growth factor-beta-signaling protein
WB, IP
Human, Rat
Phospho-Smad1 (Ser463/Ser465) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to Phospho-Smad1 (Ser463/Ser465). It can be used for WB,IP assays with tag free, in the background of Human, Rat.
MAD1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MAD2L1BP Human Pre-designed siRNA Set A contains three designed siRNAs for MAD2L1BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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