NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride

Cat. No.: HY-148819A Purity: 95.10%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro.

For research use only. We do not sell to patients.

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 424	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 975	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1561	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2900	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 6300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

509.94

Formula

C₂₆H₂₄ClN₃O₆

Appearance

Solid

Color

Yellow to brown

SMILES

NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (196.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9610 mL	9.8051 mL	19.6101 mL
5 mM	0.3922 mL	1.9610 mL	3.9220 mL
10 mM	0.1961 mL	0.9805 mL	1.9610 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.10%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (260 KB) HNMR (551 KB) LCMS (111 KB)

Handling Instructions (2659 KB)

References

[1]. Andrew C. Phillips, et al. Anti-c-met antibody drug conjugates.WO2022232834.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9610 mL	9.8051 mL	19.6102 mL	49.0254 mL
	5 mM	0.3922 mL	1.9610 mL	3.9220 mL	9.8051 mL
	10 mM	0.1961 mL	0.9805 mL	1.9610 mL	4.9025 mL
	15 mM	0.1307 mL	0.6537 mL	1.3073 mL	3.2684 mL
	20 mM	0.0981 mL	0.4903 mL	0.9805 mL	2.4513 mL
	25 mM	0.0784 mL	0.3922 mL	0.7844 mL	1.9610 mL
	30 mM	0.0654 mL	0.3268 mL	0.6537 mL	1.6342 mL
	40 mM	0.0490 mL	0.2451 mL	0.4903 mL	1.2256 mL
	50 mM	0.0392 mL	0.1961 mL	0.3922 mL	0.9805 mL
	60 mM	0.0327 mL	0.1634 mL	0.3268 mL	0.8171 mL
	80 mM	0.0245 mL	0.1226 mL	0.2451 mL	0.6128 mL
	100 mM	0.0196 mL	0.0981 mL	0.1961 mL	0.4903 mL