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Results for "

MARK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MARK (10) AAK1 (1) AMPK (7) Apoptosis (4) CDK (1) Cyclin G-associated Kinase (GAK) (1) Drug Metabolite (1) Endogenous Metabolite (3) Fluorescent Dye (2) Histamine Receptor (10) Histone Demethylase (1) Histone Methyltransferase (3) Isotope-Labeled Compounds (2) LIM Kinase (LIMK) (1) PARP (1) PROTACs (2) Salt-inducible Kinase (SIK) (3) Small Interfering RNA (siRNA) (4) Thrombin (1) Wee1 (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Endocrinology (7) Inflammation/Immunology (11) Metabolic Disease (1) Neurological Disease (5)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: MARK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101934

MARK-IN-2	MARK AMPK	Neurological Disease
MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC₅₀ of 5 nM.

HY-101933

MARK-IN-1	AMPK	Neurological Disease
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC₅₀ of <0.25 nM.

HY-112266

MARK-IN-4	MARK AMPK	Neurological Disease
MARK-IN-4 is a potent microtubule affinity regulating kinase *(MARK)* inhibitor with an IC₅₀ of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease .

HY-154988

MARK4 inhibitor 4	MARK	Neurological Disease Cancer
MARK4 inhibitor 4 is a *MARK4* inhibitor with an IC₅₀ of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .

HY-114317

MARK4 inhibitor 1	MARK AMPK Apoptosis	Cancer
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC₅₀ of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis .

HY-154986

MARK4 inhibitor 2	MARK AMPK	Cancer
MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an K_m of 6.3×10 ⁷ and an IC₅₀ of 0.82 μM. MARK4 inhibitor 2 inhibits the growth of human cells and can be used for cancer research .

HY-RS08149

MARK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MARK1 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK1 Human Pre-designed siRNA Set A MARK1 Human Pre-designed siRNA Set A

HY-RS08150

MARK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MARK2 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK2 Human Pre-designed siRNA Set A MARK2 Human Pre-designed siRNA Set A

HY-RS08151

MARK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MARK3 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK3 Human Pre-designed siRNA Set A MARK3 Human Pre-designed siRNA Set A

HY-RS08152

MARK4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MARK4 Human Pre-designed siRNA Set A contains three designed siRNAs for MARK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MARK4 Human Pre-designed siRNA Set A MARK4 Human Pre-designed siRNA Set A

HY-154987

MARK4 inhibitor 3	MARK	Cancer
MAPK4 inhibitor 3 (compound 23b) is an inhibitor of MAPK4 with an IC₅₀ value of 1.01 μM. MAPK4 inhibitor 3 inhibits cancer cells growth. MAPK4 inhibitor 3 can be used for research on cancer and tauopathies .

HY-120877A

(R)-MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for *MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis* in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .

HY-120877

MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for *MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively . MRT199665 causes apoptosis* in MEF2C-activated human acute myeloid leukemias (AML) cells . MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .

HY-159113

PCC0105003	MARK	Neurological Disease
PCC0105003 is a potent *MARK* inhibitor. PCC0105003 can be used in the study of neuropathic pain .

HY-157140

HibK	Others	Others
HibK is is a new type of histone mark that is widely distributed in histone proteins. HibK as a useful tool can be used for probing post-translational modification by site-specifically incorporate HibK into proteins .

HY-139604

PCC0208017	MARK Apoptosis	Cancer
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC₅₀s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC₅₀s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .

HY-W040254

Biotin-LC-LC-NHS	Fluorescent Dye	Others
Biotin-LC-LC-NHS is a SMCC cross-linking reagent that can be used to mark antibody and other small molecules, such as Paclitaxel .

HY-100744

AS8351 NSC51355	Histone Demethylase	Cardiovascular Disease
AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells .

HY-W004924

5-Hydroxymethyluracil	Endogenous Metabolite	Others
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1	Others
RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-N12899

9-trans-Hexadecenol	Others	Endocrinology
9-trans-Hexadecenol is a male sex pheromone that can be isolated from the labial glands of Scandinavian bumblebees (Bombus pratorum & Bombus lapidarius). 9-trans-Hexadecenol leaves marks unpredictably on small areas along the edges of birch leaves .

HY-17042

Cetirizine 2 Publications Verification	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-17042A

Cetirizine dihydrochloride 2 Publications Verification P071	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-100660A

Cetirizine Impurity B dihydrochloride	Drug Metabolite	Others
Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-100661

Cetirizine Impurity D	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-W004924S

5-Hydroxymethyluracil-d3	Endogenous Metabolite	Others
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-17042AS

Cetirizine-d4 dihydrochloride	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology
Cetirizine-d₄ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042AS1

Cetirizine-d8 dihydrochloride	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology
Cetirizine-d₈ (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S

Cetirizine-d4	Histamine Receptor	Inflammation/Immunology
Cetirizine-d₄ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-17042S1

Cetirizine-d8	Histamine Receptor	Inflammation/Immunology
Cetirizine-d₈ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

HY-P4593

Z-Gly-Pro-Arg-4MβNA	Thrombin	Others
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .

HY-17042R

Cetirizine (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-130533

ReAsH-EDT2	Fluorescent Dye	Others
ReAsH-EDT2 is a red fluorescent dye that marks proteins. ReAsH-EDT2 is a membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences which allows the protein to be imaged. ReAsH-EDT2 can be used for protein localization and trafficking. (λ_ex=530 nm, λ_em=592 nm) .

HY-17042AR

Cetirizine dihydrochloride (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology Cancer
Cetirizine (dihydrochloride) (Standard) is the analytical standard of Cetirizine (dihydrochloride). This product is intended for research and analytical applications. Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-150221

DB008	PARP	Cancer
DB008 is potent and selective PARP16 inhibitor with an IC₅₀ value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively . DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100661R

Cetirizine Impurity D (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology
Cetirizine Impurity D (Standard) is the analytical standard of Cetirizine Impurity D. This product is intended for research and analytical applications. Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-157251

UNC8153 TFA	Histone Methyltransferase	Cancer
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

HY-16986

EPZ011989 2 Publications Verification	Histone Methyltransferase	Cancer
EPZ011989 is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ011989 has inhibitory inhibition for EZH2 with a K_i value of <3 nM. EPZ011989 shows robust methyl mark inhibition and anti-tumor activity. EPZ011989 can be used for the research of various cancers . EPZ011989 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16986A

EPZ011989 trifluoroacetate 2 Publications Verification	Histone Methyltransferase	Cancer
EPZ-011989 trifluoroacetate is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ-011989 trifluoroacetate has inhibitory inhibition for EZH2 with a K_i value of <3 nM. EPZ-011989 trifluoroacetate shows robust methyl mark inhibition and anti-tumor activity. EPZ-011989 trifluoroacetate can be used for the research of various cancers . EPZ011989 (trifluoroacetate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W018324

5-Hydroxymethylcytosine 5hmC	Endogenous Metabolite	Metabolic Disease Cancer
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development .

HY-N8618

Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol	Others	Others
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

Cat. No.	Product Name

HY-L084

Microbial Metabolite Library	1,111 compounds
Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine. MCE provides a unique collection of 1,111 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Microbial Metabolite Library

1,111 compounds

Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.

MCE provides a unique collection of 1,111 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Cat. No.	Product Name	Type

HY-130533

ReAsH-EDT2	Protein Labeling
ReAsH-EDT2 is a red fluorescent dye that marks proteins. ReAsH-EDT2 is a membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences which allows the protein to be imaged. ReAsH-EDT2 can be used for protein localization and trafficking. (λ_ex=530 nm, λ_em=592 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P1583

MARK Substrate	Peptides	Inflammation/Immunology Cancer
MARK Substrate is a MARK substrate peptide.

HY-P2254

H3K27(Me3) (15-34)	Peptides	Cancer
H3K27(Me3) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

HY-P4593

Z-Gly-Pro-Arg-4MβNA	Thrombin	Others
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .

HY-P2253

H3K27(Me2) (15-34)	Peptides	Cancer
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

Species:	Human (4)
Tag:	His (2) Tag Free (2)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P701806

	MARK1 Protein, Human MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free. The total length of MARK1 Protein, Human is 751 a.a., .

HY-P701807

	MARK1 Protein, Human (His) MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MARK1 Protein, Human (His) is 751 a.a., .

HY-P701808

	MARK4 Protein, Human MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human is the recombinant human-derived MARK4 protein, expressed by E. coli , with tag free. The total length of MARK4 Protein, Human is 327 a.a., .

HY-P701809

	MARK4 Protein, Human (His) MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MARK4 Protein, Human (His) is 327 a.a., .

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