2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Cetirizine-d8

Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

For research use only. We do not sell to patients.

Cetirizine-d<sub>8</sub> Chemical Structure

Cetirizine-d8 Chemical Structure

CAS No. : 774596-22-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Cetirizine-d8:

Cetirizine-d8 Related Antibodies

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

IC50 & Target

H1 Receptor

 

Molecular Weight

396.94

Formula

C21H17D8ClN2O3
CAS No.
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)COCCN1C([2H])([2H])C([2H])([2H])N(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)C([2H])([2H])C1([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (629.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5193 mL 12.5964 mL 25.1927 mL
5 mM 0.5039 mL 2.5193 mL 5.0385 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5193 mL 12.5964 mL 25.1927 mL 62.9818 mL
5 mM 0.5039 mL 2.5193 mL 5.0385 mL 12.5964 mL
10 mM 0.2519 mL 1.2596 mL 2.5193 mL 6.2982 mL
15 mM 0.1680 mL 0.8398 mL 1.6795 mL 4.1988 mL
20 mM 0.1260 mL 0.6298 mL 1.2596 mL 3.1491 mL
25 mM 0.1008 mL 0.5039 mL 1.0077 mL 2.5193 mL
30 mM 0.0840 mL 0.4199 mL 0.8398 mL 2.0994 mL
40 mM 0.0630 mL 0.3149 mL 0.6298 mL 1.5745 mL
50 mM 0.0504 mL 0.2519 mL 0.5039 mL 1.2596 mL
60 mM 0.0420 mL 0.2099 mL 0.4199 mL 1.0497 mL
80 mM 0.0315 mL 0.1575 mL 0.3149 mL 0.7873 mL
100 mM 0.0252 mL 0.1260 mL 0.2519 mL 0.6298 mL
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Cetirizine-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetirizine-d8774596-22-4Histamine ReceptorhistamineSARARIL-1βGM-CSFIL-8SeasonalallergicrhinitisInhibitorinhibitorinhibit

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