(R)-MRT199665

Cat. No.: HY-120877A Purity: 98.70%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370.

For research use only. We do not sell to patients.

(R)-MRT199665 Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 477	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1060	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1700	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of (R)-MRT199665:

MRT199665 Get quote

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View All Salt-inducible Kinase (SIK) Isoform Specific Products:

View All Isoforms

SIK1 SIK2 SIK3

View All AMPK Isoform Specific Products:

View All Isoforms

NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

469.58

Formula

C₂₈H₃₁N₅O₂

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C)(C)C2=CN=C(NC3=CC=CC(CN4CCCC4)=C3)N=C2N1[C@@H]5CCC6=C5C=CC=C6O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.70%

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Data Sheet (269 KB) SDS (251 KB)

COA (250 KB) HNMR (272 KB) RP-HPLC (265 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. [Content Brief]

[2]. Brown FC, et al. MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. Cancer Discov. 2018 Apr;8(4):478-497. [Content Brief]

[3]. Hutchinson LD, et al. Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.Cell Death Dis. 2020 Jan 22;11(1):49. [Content Brief]

(R)-MRT199665 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-MRT199665MARKSalt-inducible Kinase (SIK)AMPKApoptosisMicrotubule affinity regulating kinaseAMP-activated protein kinaseIsoformsSIKAMLphosphorylationInhibitorinhibitorinhibit

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