2. Cell Cycle/DNA Damage
  3. MARK
  4. MARK4 inhibitor 3

MAPK4 inhibitor 3 (compound 23b) is an inhibitor of MAPK4 with an IC50 value of 1.01 μM. MAPK4 inhibitor 3 inhibits cancer cells growth. MAPK4 inhibitor 3 can be used for research on cancer and tauopathies.

For research use only. We do not sell to patients.

MARK4 inhibitor 3 Chemical Structure

MARK4 inhibitor 3 Chemical Structure

Size Price Stock Quantity
5 mg USD 170 In-stock
10 mg USD 270 In-stock
25 mg USD 540 In-stock
50 mg USD 860 In-stock
100 mg USD 1380 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

MARK4 inhibitor 3 Related Antibodies

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Description

MAPK4 inhibitor 3 (compound 23b) is an inhibitor of MAPK4 with an IC50 value of 1.01 μM. MAPK4 inhibitor 3 inhibits cancer cells growth. MAPK4 inhibitor 3 can be used for research on cancer and tauopathies[1].

IC50 & Target

Microtubule affinity-regulating kinase 4 (MARK4)[1] IC50:1.01 μM (Microtubule affinity-regulating kinase 4, MARK4)[1]
In Vitro

MAPK4 inhibitor 3 (1-20 μM, 24 h) inhibits Hela and U87MG growth with EC50 values of 2.52 μM and 4.22 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MARK4 inhibitor 3 Related Antibodies

Cell Viability Assay[1]

Cell Line: Hela, U87MG
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Inhibited cell growth with EC50 values of 2.52 μM (Hela), 4.22 μM (U87MG).
Molecular Weight

546.59

Formula

C33H27FN4O3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(F)C=C1)[C@@H](NC(CN(C2=C3C=CC=C2)C4=CC=C(C)C=C4C3=O)=O)CC5=CNC6=C5C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (228.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8295 mL 9.1476 mL 18.2952 mL
5 mM 0.3659 mL 1.8295 mL 3.6590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8295 mL 9.1476 mL 18.2952 mL 45.7381 mL
5 mM 0.3659 mL 1.8295 mL 3.6590 mL 9.1476 mL
10 mM 0.1830 mL 0.9148 mL 1.8295 mL 4.5738 mL
15 mM 0.1220 mL 0.6098 mL 1.2197 mL 3.0492 mL
20 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2869 mL
25 mM 0.0732 mL 0.3659 mL 0.7318 mL 1.8295 mL
30 mM 0.0610 mL 0.3049 mL 0.6098 mL 1.5246 mL
40 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL
50 mM 0.0366 mL 0.1830 mL 0.3659 mL 0.9148 mL
60 mM 0.0305 mL 0.1525 mL 0.3049 mL 0.7623 mL
80 mM 0.0229 mL 0.1143 mL 0.2287 mL 0.5717 mL
100 mM 0.0183 mL 0.0915 mL 0.1830 mL 0.4574 mL
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MARK4 inhibitor 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MARK4 inhibitor 3MARKMicrotubule affinity regulating kinaseHelaU87MGanticancertauopathiesInhibitorinhibitorinhibit

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