2. Cell Cycle/DNA Damage
  3. MARK
  4. MARK4 inhibitor 4

MARK4 inhibitor 4 is a MARK4 inhibitor with an IC50 of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research.

For research use only. We do not sell to patients.

MARK4 inhibitor 4 Chemical Structure

MARK4 inhibitor 4 Chemical Structure

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Based on 1 publication(s) in Google Scholar

MARK4 inhibitor 4 Related Antibodies

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  • Purity & Documentation

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Description

MARK4 inhibitor 4 is a MARK4 inhibitor with an IC50 of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research[1].

IC50 & Target

IC50: 1.49 μM (MARK4)
In Vitro

MARK4 inhibitor 4 (Compound 23c) (1-20 μM; 24 h) has obvious inhibitory effect on the growth of Hela and U87MG cells, with EC50s value of 2.16 and 3.51 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MARK4 inhibitor 4 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Hela, U87MG, U251, MDA-MB-435, HGFs cells
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Showed obvious cytotoxicity in Hela and U87MG cell lines.
Molecular Weight

563.05

Formula

C33H27ClN4O3
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(Cl)C=C1)[C@@H](NC(CN(C2=C3C=CC=C2)C4=CC=C(C)C=C4C3=O)=O)CC5=CNC6=C5C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7760 mL 8.8802 mL 17.7604 mL
5 mM 0.3552 mL 1.7760 mL 3.5521 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (4.44 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7760 mL 8.8802 mL 17.7604 mL 44.4010 mL
5 mM 0.3552 mL 1.7760 mL 3.5521 mL 8.8802 mL
10 mM 0.1776 mL 0.8880 mL 1.7760 mL 4.4401 mL
15 mM 0.1184 mL 0.5920 mL 1.1840 mL 2.9601 mL
20 mM 0.0888 mL 0.4440 mL 0.8880 mL 2.2201 mL
25 mM 0.0710 mL 0.3552 mL 0.7104 mL 1.7760 mL
30 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4800 mL
40 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1100 mL
50 mM 0.0355 mL 0.1776 mL 0.3552 mL 0.8880 mL
60 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7400 mL
80 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5550 mL
100 mM 0.0178 mL 0.0888 mL 0.1776 mL 0.4440 mL
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MARK4 inhibitor 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MARK4 inhibitor 4MARKMicrotubule affinity regulating kinasecancer HelaU87MGU251MDA-MB-435HGFs cellsInhibitorinhibitorinhibit

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