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Mycobacterial tuberculosis

" in MedChemExpress (MCE) Product Catalog:

33

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3

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1

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3

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Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1046
    Clofazimine
    Maximum Cited Publications
    6 Publications Verification

    		 Bacterial Antibiotic DNA/RNA Synthesis Interleukin Related Apoptosis Infection Inflammation/Immunology Cancer
    Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC50 = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .
    Clofazimine
  • HY-109588
    NITD-349
    1 Publications Verification

    		 Bacterial Infection
    NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.
    NITD-349
  • HY-P3270
    Capreomycin

    		Bacterial Antibiotic Infection
    Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation
    Capreomycin
  • HY-117145
    Thiophene-2

    		Bacterial Infection
    Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .
    Thiophene-2
  • HY-120884
    InhA-IN-5

    		Bacterial Infection
    InhA-IN-5 (compound 1) is a potent Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA) inhibitor .
    InhA-IN-5
  • HY-B1046R
    Clofazimine (Standard)

    		Bacterial Antibiotic DNA/RNA Synthesis Interleukin Related Apoptosis Infection Inflammation/Immunology Cancer
    Clofazimine (Standard) is the analytical standard of Clofazimine. This product is intended for research and analytical applications. Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC50 = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .
    Clofazimine (Standard)
  • HY-152035
    Mycobacterial Zmp1-IN-1

    		Bacterial Infection Inflammation/Immunology
    Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB) .
    Mycobacterial Zmp1-IN-1
  • HY-142031
    4-Piperidinecarboxamide

    		Bacterial Infection
    4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .
    4-Piperidinecarboxamide
  • HY-150967
    MmpL3-IN-1

    		Bacterial Infection
    MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .
    MmpL3-IN-1
  • HY-151356
    Antibacterial agent 122

    		Bacterial Infection
    Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .
    Antibacterial agent 122
  • HY-151354
    Antibacterial agent 121

    		Bacterial Infection
    Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research .
    Antibacterial agent 121
  • HY-162836
    Rifamycin B

    4-O-(Carboxymethyl)-Rifamycin

    		 Antibiotic Bacterial Infection
    Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a metabolic product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation .
    Rifamycin B
  • HY-109587
    BM635

    		Bacterial Infection
    BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC50 of 0.12 μM against M. tuberculosis H37Rv.
    BM635
  • HY-146158
    WX-081

    		Bacterial Potassium Channel Antibiotic Infection
    WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM.
    WX-081
  • HY-100725
    BM212
    3 Publications Verification

    		 Bacterial Infection
    BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .
    BM212
  • HY-45854
    GWP-042
    1 Publications Verification

    		 Bacterial Infection
    GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo .
    GWP-042
  • HY-151205
    Antituberculosis agent-3

    		Bacterial Infection Inflammation/Immunology
    Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .
    Antituberculosis agent-3
  • HY-109587B
    BM635 mesylate

    		Bacterial Infection
    BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC50 of 0.6 μM against M. tuberculosis  H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635 .
    BM635 mesylate
  • HY-158380
    UH-NIP-16

    		Bacterial Infection
    UH-NIP-16 exhibits antimicrobial activity against Mycobacterium tuberculosis, with MIC50 of 1.86 and 3.05 μM, for pathogenic mycobacterial strains H37Rv and CDC1551. UH-NIP-16 synergizes with Streptomycin (HY-B1906), Isoniazid (HY-B0329), Ethambutol (HY-B0535) and Bedaquiline (HY-14881), potentiates their anti-tuberculosis activities .
    UH-NIP-16
  • HY-109587A
    BM635 hydrochloride

    		Bacterial Infection
    BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635 .
    BM635 hydrochloride
  • HY-151204
    PknB-IN-1

    		Bacterial Infection Inflammation/Immunology
    PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL) .
    PknB-IN-1
  • HY-100750
    Norverapamil hydrochloride
    1 Publications Verification

    (±)-Norverapamil hydrochloride; D591 hydrochloride

    		 Calcium Channel P-glycoprotein Drug Metabolite Cardiovascular Disease
    Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .
    Norverapamil hydrochloride
  • HY-135328
    Norverapamil

    (±)-Norverapamil; D591

    		 Calcium Channel P-glycoprotein Drug Metabolite Cardiovascular Disease
    Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .
    Norverapamil
  • HY-120733
    Calpinactam

    FKI-4905

    		 Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
    Calpinactam
  • HY-147704
    Antimycobacterial agent-2

    		Bacterial Infection
    Antimycobacterial agent-2 (compound 58) is a potent antimycobacterial agent. Antimycobacterial agent-2 shows anti-mycobacterial activities with an MIC99 of 0.8 µM for Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 shows cytotoxic activities with an IC50 of48.1 µM for CHO cells .
    Antimycobacterial agent-2
  • HY-162804
    ATP synthase inhibitor 3

    		Bacterial ATP Synthase Infection
    ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC50=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC50 value of 30μM .
    ATP synthase inhibitor 3
  • HY-17566
    Capreomycin sulfate
    2 Publications Verification

    		 Antibiotic Bacterial Infection Neurological Disease Metabolic Disease
    Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease .
    Capreomycin sulfate
  • HY-122643
    NITD-916

    		Bacterial Infection
    NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects .
    NITD-916
  • HY-135328S
    Norverapamil-d7

    (±)-Norverapamil-d7; D591-d7

    		 Calcium Channel P-glycoprotein Drug Metabolite Cardiovascular Disease
    Norverapamil-d7 is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].
    Norverapamil-d7
  • HY-118061
    VCC234718

    		Others Infection
    VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site .
    VCC234718
  • HY-161802
    Antibacterial agent 228

    		Bacterial Infection
    Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC50 for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessus ATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .
    Antibacterial agent 228
  • HY-17566R
    Capreomycin sulfate (Standard)

    		Antibiotic Bacterial Infection Neurological Disease Metabolic Disease
    Capreomycin (sulfate) (Standard) is the analytical standard of Capreomycin (sulfate). This product is intended for research and analytical applications. Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease .
    Capreomycin sulfate (Standard)
  • HY-W250306
    Carbol fuchsin

    		Biochemical Assay Reagents Others
    Carbol fuchsin is a histological stain used in microbiology to distinguish acid-fast bacteria from non-acid-fast bacteria. It is a mixture of basic fuchsin, phenol, and water and is commonly used in the Ziehl-Neelsen staining technique for the detection of tuberculosis and other mycobacterial infections. Carbol fuchsin stains the cell walls of acid-fast bacteria bright red, while other cells are unstained or slightly stained. This makes it easier to see and identify these microbes under a microscope. Carbol fuchsin is also used in veterinary medicine and phytopathology for similar purposes.
    Carbol fuchsin

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