Antibacterial agent 122

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Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies.

For research use only. We do not sell to patients.

Antibacterial agent 122 Chemical Structure

CAS No. : 109310-99-8

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Biological Activity
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Description

Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	CC₅₀	196.7 μM Compound: 15	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 34890996]
RAW264.7	IC₅₀	28.4 μM Compound: 15	Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA	[PMID: 34890996]
RAW264.7	IC₅₀	47.9 μM Compound: 15	Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA	[PMID: 34890996]
RAW264.7	IC₅₀	8.1 μM Compound: 15	Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis	[PMID: 34890996]

In Vitro

Antibacterial agent 122 (compound 15) (25-200 µM, 24 h) inhibits M. tuberculosis H37Rv with the MIC₅₀ value of 5.9 µM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC₅₀ value of 8.1µM^[1].
Antibacterial agent 122 (compound 15) (25-200 µM) acts on NO scavenging with an IC₅₀ value of 184.2 µM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 µM^[1].
Antibacterial agent 122 (compound 15) (0-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC₅₀ values of 28.4 µM and 47.9 µM, respectively^[1].
Antibacterial agent 122 (compound 15) (25-100 µM, 4 days) inhibits M. tuberculosis M299 with an MIC₅₀ value of 24.7 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.35

Formula

C₁₅H₁₄N₂O₃S

CAS No.

109310-99-8

SMILES

O=C(O)C1=CC=C(NC(NCC2=CC=CC=C2)=S)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506. [Content Brief]