Capreomycin sulfate

Name: Capreomycin sulfate
Brand: MedChemExpress
SKU: HY-17566
Rating: 5.0 (2 reviews)

Cat. No.: HY-17566 Purity: 99.52%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease.

For research use only. We do not sell to patients.

Capreomycin sulfate Chemical Structure

CAS No. : 1405-37-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 116	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 116	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 105	In-stock	Estimated Time of Arrival: December 31
1 g	USD 180	In-stock	Estimated Time of Arrival: December 31
5 g	USD 480	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Capreomycin sulfate:

Capreomycin Get quote
Capreomycin sulfate (Standard) Get quote

2 Publications Citing Use of MCE Capreomycin sulfate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Aminoglycoside

In Vitro

Capreomycin sulfate (10-200 μM; 80 h) inhibits the formation of insulin fibrils in human erythrocytes in a concentration-dependent manner (IC₅₀=69.98 µM) and has a delayed fibrillation process^[3].
Capreomycin sulfate (75-100 μM; 60 min) shows a dose-dependent protective effect against amyloid fibril-induced erythrocyte damage and hemolysis^[3].
Capreomycin sulfate (100 μM; 0-48 h) effectively destroys fibrils in erythrocytes in a time-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	human erythrocyte
Concentration:	75 and 100 µM
Incubation Time:	30 min
Result:	The hemolysis rates were 23.8% and 13.0% at 75µM and 100µM, respectively.

In Vivo

Capreomycin sulfate (1.4-14.5 mg/kg for insufflation; 20 mg/kg for i.m., 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs^[2]。

Pharmacokinetic Analysis in the guinea pig model^[2]

Route	Dose (mg/kg)	AUC_0-t (ng•h/mL)	CL_F (mL/h•kg)	K (h^-1)	t_1/2 (h)	MRT (h)	C_max (ng/mL)	T_max (h)	MAT (h)	F_0-t
i.v.	20	49.29	0.42	0.92	0.75	0.88	53.36	0.08	/	1.00
i.m.	20	58.2	0.35	0.68	1.09	1.44	32.33	0.36	0.44	1.20
Insufflation	14.5	16.95	0.54	0.48	1.53	1.80	6.70	0.31	0.80	0.54
Insufflation	7.2	8.2	0.52	0.45	1.68	1.72	3.34	0.38	0.72	0.59
Insufflation	1.4	1.15	0.67	0.71	1.22	1.01	0.92	0.5	/	0.41

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 105 CFU/mL of Mycobacterium tuberculosis (strain H37Rv)] ^[2]
Dosage:	1.4, 7.2, and 14.5 mg/kg for Insufflation; 20 mg/kg for Intramuscular injection
Administration:	Insufflation or Intramuscular injection; 4 weeks
Result:	Decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls. Lowered bacterial burden in the lungs (3.52 CFU/mL) at 14.5 mg/kg than controls (4.58 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 and 4.01 CFU/mL, respectively)

Clinical Trial

Molecular Weight

638.61

Formula

C₁₉H₃₄N₁₂O₁₁S

CAS No.

1405-37-4

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CNC([C@H]([C@H]1CCNC(N1)=N)NC(/C2=C/NC(N)=O)=O)=O)C(N[C@@H](CO)C(N[C@H](C(N2)=O)CN)=O)=O.O=S(O)(O)=O

Structure Classification

Initial Source

Microorganisms

Streptomyces capreolus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 37 mg/mL (57.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5659 mL	7.8295 mL	15.6590 mL
5 mM	0.3132 mL	1.5659 mL	3.1318 mL
10 mM	0.1566 mL	0.7830 mL	1.5659 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (156.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.52%

Select Batch:

Data Sheet (283 KB) SDS (393 KB)

COA (253 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Maus CE, et al. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2005 Feb;49(2):571-7. [Content Brief]

[2]. Garcia-Contreras L, et al. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 2007 Aug;51(8):2830-6. [Content Brief]

[3]. Siddiqi M K, et al. Capreomycin inhibits the initiation of amyloid fibrillation and suppresses amyloid induced cell toxicity[J]. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2018, 1866(4): 549-557. [Content Brief]

[4]. Reisfeld B, et al. A physiologically based pharmacokinetic model for capreomycin[J]. Antimicrobial agents and chemotherapy, 2012, 56(2): 926-934. [Content Brief]

[5]. Le Conte P, et al. Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model[J]. Antimicrobial agents and chemotherapy, 1994, 38(12): 2695-2701. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5659 mL	7.8295 mL	15.6590 mL	39.1475 mL
	5 mM	0.3132 mL	1.5659 mL	3.1318 mL	7.8295 mL
	10 mM	0.1566 mL	0.7830 mL	1.5659 mL	3.9148 mL
	15 mM	0.1044 mL	0.5220 mL	1.0439 mL	2.6098 mL
	20 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9574 mL
	25 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5659 mL
	30 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3049 mL
	40 mM	0.0391 mL	0.1957 mL	0.3915 mL	0.9787 mL
	50 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7830 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.