Rifamycin B  (Synonyms: 4-O-(Carboxymethyl)-Rifamycin)

Rifamycin B (4-O-(Carboxymethyl)-Rifamycin) is a member of ansamycin antibiotics family with an anti-mycobacterial activity against tuberculosis, leprosy and AIDS-related mycobacterial infections. Rifamycin B is a metabolic product of Nocardia inediterranei, which can yield Rifamycin O and Rifamycin S (HY-125365) by microbial transformation^[1][2].

755.80

C₃₉H₄₉NO₁₄

13929-35-6

C/C(C(N1)=O)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]([C@@H](OC)/C=C/O[C@]2(C)C(C3=C(O2)C(C)=C(O)C4=C3C(OCC(O)=O)=CC1=C4O)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Seong BL, et al. Microbial transformation of rifamycin B: a new synthetic approach to rifamycin derivatives. J Antibiot (Tokyo). 1983 Oct;36(10):1402-4.  [Content Brief]

  [2]. Jin ZH, et al. Scale-up of rifamycin B fermentation with Amycolatoposis mediterranei. J Zhejiang Univ Sci. 2004 Dec;5(12):1590-6.  [Content Brief]