2. Anti-infection
  3. Bacterial
  4. NITD-916

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects.

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NITD-916 Chemical Structure

NITD-916 Chemical Structure

CAS No. : 1614262-83-7

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1 mg USD 400 In-stock
5 mg USD 965 In-stock
10 mg USD 1340 In-stock
25 mg USD 1920 In-stock
50 mg USD 2350 In-stock
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Description

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects[1][2].

IC50 & Target

IC50: 570 nM (InhA)[1]
Molecular Weight

311.42

Formula

C20H25NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=CC=CC=C2)=C(O)C=C(CC3CCC(C)(C)CC3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.5 mg/mL (56.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2111 mL 16.0555 mL 32.1110 mL
5 mM 0.6422 mL 3.2111 mL 6.4222 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2111 mL 16.0555 mL 32.1110 mL 80.2774 mL
5 mM 0.6422 mL 3.2111 mL 6.4222 mL 16.0555 mL
10 mM 0.3211 mL 1.6055 mL 3.2111 mL 8.0277 mL
15 mM 0.2141 mL 1.0704 mL 2.1407 mL 5.3518 mL
20 mM 0.1606 mL 0.8028 mL 1.6055 mL 4.0139 mL
25 mM 0.1284 mL 0.6422 mL 1.2844 mL 3.2111 mL
30 mM 0.1070 mL 0.5352 mL 1.0704 mL 2.6759 mL
40 mM 0.0803 mL 0.4014 mL 0.8028 mL 2.0069 mL
50 mM 0.0642 mL 0.3211 mL 0.6422 mL 1.6055 mL
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NITD-916 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NITD-9161614262-83-7NITD916NITD 916Bacterial4-hydroxy-2-pyridonemultidrug-resistanttuberculosisorallylipophilicInhAInhibitorinhibitorinhibit

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