2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 121

Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research.

For research use only. We do not sell to patients.

Antibacterial agent 121 Chemical Structure

Antibacterial agent 121 Chemical Structure

CAS No. : 474099-18-8

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Antibacterial agent 121 Related Antibodies

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Description

Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 CC50
≥ 200 μM
Compound: 10
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 34890996]
RAW264.7 IC50
15.3 μM
Compound: 10
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
4.1 μM
Compound: 10
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
[PMID: 34890996]
RAW264.7 IC50
80.2 μM
Compound: 10
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
[PMID: 34890996]
In Vitro

Antibacterial agent 121 (0.2-200 µM; 24 h) inhibits M. tuberculosis H37Rv growth in bacterial culture[1].
Antibacterial agent 121 (0-200 µM; 24 h) inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 4.1 µM[1].
Antibacterial agent 121 (6.25-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages[1].
Antibacterial agent 121 (25-100 µM, 4 d) inhibits M. tuberculosis M299 with an MIC50 value of 24.8 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 121 Related Antibodies

Cell Viability Assay[1]

Cell Line: M. tuberculosis H37Rv
Concentration: 0.2-200 µM
Incubation Time: 24 hours
Result: Inhibited Mtb H37Rv growth with MIC50 of 8.6 µM.

Cell Viability Assay[1]

Cell Line: RAW 264.7 macrophages and J774A.1 macrophages
Concentration: 6.25-200 µM
Incubation Time: 24 hours
Result: Showed IC50 values of 15.3 µM and 28.4 µM for TNF-α and IL-1β production, respectively.
Molecular Weight

346.44

Formula

C18H22N2O3S
CAS No.
SMILES

S=C(NC1=CC(OC)=C(OC)C(OC)=C1)NCCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 121 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 121474099-18-8Antibacterial agent121Antibacterial agent-121Bacterialanti-mycobacterial activityanti-inflammatory activityTuberculosisTBInhibitorinhibitorinhibit

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