2. Anti-infection
  3. Bacterial
  4. BM635 hydrochloride

BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635.

For research use only. We do not sell to patients.

BM635 hydrochloride Chemical Structure

BM635 hydrochloride Chemical Structure

CAS No. : 2748337-90-6

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Description

BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635[1].

IC50 & Target

MIC50: 0.08 μM (M. tuberculosis H37Rv)[1]
In Vivo

BM635 hydrochloride (oral administration; 50 mg/Kg) results in gradual elevations in blood up to a Cmax of 579.1 ng/ml with Tmax of 3 hour. It doubles the in vivo exposure with respect to the free base BM635 in C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

428.97

Formula

C25H30ClFN2O
CAS No.
SMILES

CC(C1=CC=C(C2=CC(CN3CCOCC3)=C(C)N2C4=CC=C(F)C=C4)C=C1)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BM635 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BM6352748337-90-6BM 635BM-635Bacterialanti-mycobacterialM.tuberculosisMycobacteriumInhibitorinhibitorinhibit

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BM635 hydrochloride
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