Mycobacterial Zmp1-IN-1 

Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB)^[1].

Mycobacterial Zmp1-IN-1 (Compound 2f) has antimycobacterial activity for M. bovis and Mtb H37Ra in dose-dependent inhibition^[1].
Mycobacterial Zmp1-IN-1 has no acute cellular toxicity against the RAW 264.7 and MRC-5 cell line with IC₅₀ values both of ＞128 μM^[1].
Mycobacterial Zmp1-IN-1 (8 μM, 32 μM, 128 μM) induces a reduction of bacterial survival within the macrophage host cell^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

525.57

C₂₆H₂₇N₃O₇S

3033421-29-0

COC([C@H](C(C)C)NC(C1=CC=C(C=C1)/C=C2SC(N(C\2=O)CC(NOCC3=CC=CC=C3)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Milan Dak, et al. Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function. Eur J Med Chem. 2022 Dec 15;244:114831.  [Content Brief]