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Results for "

P16

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apoptosis (1) Bcl-2 Family (1) Biochemical Assay Reagents (2) BMI1 (1) Histone Methyltransferase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Endocrinology (1) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119344

MS37452 1 Publications Verification	Histone Methyltransferase	Cancer
MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a K_d of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells .

HY-165997

1-1(Z)-Hexadecenyl-2-Palmitoyl-sn-glycero-3-PC PC-(P16:0/16:0)	Biochemical Assay Reagents	Metabolic Disease
1-1(Z)-Hexadecenyl-2-Palmitoyl-sn-glycero-3-PC is an ester product.

HY-RS16296

P16 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P16 Human Pre-designed siRNA Set A contains three designed siRNAs for P16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components P16 siRNA-1: 5 nmol (HPLC) P16 siRNA-2: 5 nmol (HPLC) P16 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

P16 Human Pre-designed siRNA Set A

Small Interfering RNA (siRNA)

Others

P16 Human Pre-designed siRNA Set A contains three designed siRNAs for P16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Components

P16 siRNA-1: 5 nmol (HPLC)

P16 siRNA-2: 5 nmol (HPLC)

P16 siRNA-3: 5 nmol (HPLC)

siRNA Negative Control: 5 nmol (HPLC)

FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

GAPDH siRNA Positive Control: 5 nmol (HPLC)

P16 Human Pre-designed siRNA Set A P16 Human Pre-designed siRNA Set A

HY-N0992

1,6,7-Trihydroxyxanthone	BMI1 Apoptosis	Cancer
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16 .

HY-169265

BRD-K20733377	Bcl-2 Family	Others
BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC₅₀ of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model .

HY-168895

c-Fos-IN-1	AP-1	Cancer
c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC₅₀: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth .

HY-N7241

Saudin	Others	Endocrinology
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

HY-165157

1-1(Z)-Hexadecenyl-2-arachidonoyl-sn-glycero-3-PC 16:0p/20:4-PC; PC(P-16:0/20:4); C16(plasm)-20:4-PC	Biochemical Assay Reagents	Others
1-1(Z)-Hexadecenyl-2-arachidonoyl-sn-glycero-3-PC 是一种生化试剂。

Cat. No.	Product Name

HY-L077

Anti-Pancreatic Cancer Compound Library	3,124 compounds
Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer. MCE offers a unique collection of 3,124 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Anti-Pancreatic Cancer Compound Library

3,124 compounds

Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer.

MCE offers a unique collection of 3,124 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P10324

TAT-p16 P16^INK4a peptide	Peptides	Cancer
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .

HY-P3602

C3 Peptide P16	Peptides	Cancer
C3 Peptide P16, is a 16 amino acid synthetic peptide derived from human C3d, a fragment generated in trypsin-cleaved C3. C3 Peptide P16 enhances in vitro phosphorylation of pp105 and pp100, a cellular component presenting in the human B lymphoma cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0992

1,6,7-Trihydroxyxanthone	Structural Classification Natural Products Goodyera oblongifolia Raf. Orchidaceae Source classification Plants	BMI1 Apoptosis
1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16 .

HY-N7241

Saudin	Clutia lanceolata Forssk. Structural Classification Other Monoterpenes Terpenoids Source classification Euphorbiaceae Plants	Others
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

Cat. No.	Compare	Product Name	Species	Source

HY-P72785

	CDKN2A Protein, Human Cyclin-dependent kinase inhibitor 2A; CDK4I; MTS-1; P16INK4A	Human	E. coli
	CDKN2A Protein, a potent negative regulator of cell proliferation, forms strong interactions with CDK4 and CDK6, hindering their association with cyclins D and retinoblastoma protein phosphorylation. Acting in a heterodimeric manner, predominantly with CDK6, CDKN2A inhibits cyclin D-CDK4 kinase activity and interacts with ISCO2, contributing to its cell cycle regulatory role. CDKN2A Protein, Human is the recombinant human-derived CDKN2A protein, expressed by E. coli , with tag free. The total length of CDKN2A Protein, Human is 155 a.a., with molecular weight of ~19.12 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-P10324

TAT-p16
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80992

	*CDKN2A/p16INK4a Antibody* ARF antibody; CDK4 inhibitor P16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; INK4 antibody; INK4a antibody; Melanoma P16 inhibits CDK4 antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; P16 antibody; P16 INK4a antibody; P16INK4a antibody; p19 antibody; P19ARF antibody; TP16 antibody;	WB, IHC-P	Human
	CDKN2A/p16INK4a Antibody is an unconjugated, approximately 16 kDa, rabbit-derived, anti-CDKN2A/p16INK4a monoclonal antibody. CDKN2A/p16INK4a Antibody can be used for: WB, IHC-P expriments in human background without labeling.

HY-P80615

	*CDKN2A/p16INK4a Antibody (YA508)* CDK4 inhibitor P16 INK4 antibody; CDK4I antibody; CDKN2 antibody; CDKN2A antibody; Cell cycle negative regulator beta antibody; CMM2 antibody; Cyclin dependent kinase 4 inhibitor A antibody; Cyclin dependent kinase inhibitor 2A (melanoma P16 inhibits CDK4) antibody; Cyclin Dependent Kinase Inhibitor 2A antibody; Cyclin dependent kinase inhibitor 2A isoform 4 antibody; Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody; Cyclin dependent kinase inhibitor P16 antibody; INK4 antibody; INK4A antibody; MLM antibody; MTS1 antibody; Multiple tumor suppressor 1 antibody; p14 antibody; P16 antibody; P16INK4 antibody; P16INK4a antibody; p19 antibody; p19Arf antibody; TP16 antibody	WB, IP	Human, Mouse
	CDKN2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to CDKN2A. It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P82109

	p16 ARC Antibody (YA1854) P16 Arc; ARPC5; ARC16; Arp2/3 protein complex subunit P16	WB, IHC-P, IP	Human, Mouse, Rat
	p16 ARC Antibody (YA1854) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1854), targeting p16 ARC, with a predicted molecular weight of 16 kDa (observed band size: 16 kDa). p16 ARC Antibody (YA1854) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.