2. Immunology/Inflammation
  3. AP-1
  4. c-Fos-IN-1

c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth.

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c-Fos-IN-1 Chemical Structure

c-Fos-IN-1 Chemical Structure

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c-Fos-IN-1 Related Antibodies

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c-Fos c-Jun

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Description

c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1].

IC50 & Target[1]

c-Fos

 

c-Jun

 

Molecular Weight

433.58

Formula

C28H35NO3
SMILES

C=C1CCC2([C@@](C)([C@@H](CC[C@]2([C@@H]1/C=C/C(C(N/3)=O)=CC3=C\C4=CC=C(C=C4)C)C)O)CO)[H]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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c-Fos-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Fos-IN-1AP-1Activator Protein 1MGC-803gastric canceranticancercell cycletumor growthMGC-803 xenograftInhibitorinhibitorinhibit

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