2. Search Result
Search Result
Results for "

PDT

" in MedChemExpress (MCE) Product Catalog:

39

Inhibitors & Agonists

2

Fluorescent Dye

2

Peptides

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2213A
    GPLGIAGQ TFA

    		MMP Apoptosis Cancer
    GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
    GPLGIAGQ TFA
  • HY-137475
    Chlorin e6 trimethyl ester
    1 Publications Verification

    		 Reactive Oxygen Species Cancer
    Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT) .
    Chlorin e6 trimethyl ester
  • HY-U00128
    PPA-904

    		Parasite Infection Inflammation/Immunology
    PPA-904 is a specific phenothiazine photosensitizer in photodynamic research (PDT) research, especially topical application for cutaneous leishmaniasis in vivo .
    PPA-904
  • HY-16045
    Hexaminolevulinate hydrochloride

    Hexyl 5-aminolevulinate hydrochloride; P-1206; 5-Aminolevulinic acid hexyl ester hydrochloride

    		 Fluorescent Dye Cancer
    Hexaminolevulinate (Hexyl 5-aminolevulinate) hydrochloride, a porphyrin precursor, is a photosensitiser that can be used in photodynamic therapy (PDT) for certain tumor. Hexaminolevulinate hydrochloride can improve the visualisation of bladder tumours .
    Hexaminolevulinate hydrochloride
  • HY-19204
    Zinc phthalocyanine

    ZnPc

    		 Fluorescent Dye Cancer
    Zinc phthalocyanine (ZnPc) is commonly applied in industry (catalysts, photoconductors) and biomedical (photodynamic therapy, PDT). Zinc phthalocyanine can be used to photooxidise cyclohexane and is promising for research of solar-cell applications .
    Zinc phthalocyanine
  • HY-157943
    Hexyl 5-aminolevulinate

    HAL

    		 Fluorescent Dye Cancer
    Hexyl 5-aminolevulinate (HAL) is a photosensitizer, and can increase the efficiency of PDT due to the high lipophilicity. Hexyl 5-aminolevulinate can be used for research of photodynamic therapy (PDT) .
    Hexyl 5-aminolevulinate
  • HY-P2213
    GPLGIAGQ

    		MMP Apoptosis Cancer
    GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .
    GPLGIAGQ
  • HY-137474
    Purpurin 18 methyl ester

    		Others Cancer
    Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death .
    Purpurin 18 methyl ester
  • HY-162824
    Antitumor photosensitizer-6

    		Apoptosis Cancer
    Antitumor photosensitizer-6 (Compound Ru2) shows synergetic type I/II photosensitization and photocatalytic activity upon 595 nm light excitation. Ru2 induces intracellular redox imbalance and affects the biosynthetic and metabolic processes, leading to cell apoptosis. Antitumor photosensitizer-6 can be used for research of photodynamic therapy (PDT) .
    Antitumor photosensitizer-6
  • HY-155003
    TPEQM-DMA

    		Fluorescent Dye Cancer
    TPEQM-DMA is a NIR-II photosensitizer. TPEQM-DMA accumulates in cancerous mitochondria, and inhibits cancer cell growth. TPEQM-DMA has potent type-I phototherapeutic efficacy to overcome the intrinsic pitfalls of PDT in combating hypoxic tumors .
    TPEQM-DMA
  • HY-A0169A
    Methyl aminolevulinate hydrochloride
    1 Publications Verification

    		 Reactive Oxygen Species Inflammation/Immunology Cancer
    Methyl aminolevulinate hydrochloride is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX .
    Methyl aminolevulinate hydrochloride
  • HY-A0169
    Methyl aminolevulinate

    		Reactive Oxygen Species Inflammation/Immunology Cancer
    Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX .
    Methyl aminolevulinate
  • HY-N10611
    Elsinochrome A

    		Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye Infection Cancer
    Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .
    Elsinochrome A
  • HY-137473
    Methyl pyropheophorbide-a
    1 Publications Verification

    Pyropheophorbide-a methyl ester

    		 Apoptosis Cancer
    Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth .
    Methyl pyropheophorbide-a
  • HY-16488
    Temoporfin
    Maximum Cited Publications
    10 Publications Verification

    m-THPC; KW2345

    		 Reactive Oxygen Species Cancer
    Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers .
    Temoporfin
  • HY-149778
    Antifungal agent 87

    		Fungal Infection
    Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC50 = 1 nM for T. rubrum) .
    Antifungal agent 87
  • HY-116525
    Octaethylporphyrin

    		Reactive Oxygen Species Cancer
    Octaethylporphyrin is a porphyrin derivative. Octaethylporphyrin is a photodynamic therapy (PDT) agent .
    Octaethylporphyrin
  • HY-13722
    HPPH
    3 Publications Verification

    Photochlor

    		 Reactive Oxygen Species Cancer
    HPPH (Photochlor) is a second generation photosensitizer, which acts as a photodynamic therapy (PDT) agent.
    HPPH
  • HY-16477
    Talaporfin sodium
    3 Publications Verification

    ME2906; Mono-L-aspartyl chlorin e6; NPe6

    		 Others Cancer
    Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) .
    Talaporfin sodium
  • HY-D1673
    Tetrabromorhodamine 123 bromide

    		Fluorescent Dye Cancer
    Tetrabromorhodamine 123 (TBR) bromide is a photosensitizer. Tetrabromorhodamine 123 bromide can be used for the research of photo dynamic therapy (PDT) and cancer .
    Tetrabromorhodamine 123 bromide
  • HY-16477A
    Talaporfin

    ME2906 free acid; Mono-L-aspartyl chlorin e6 free acid; NPe6 free acid

    		 Others Cancer
    Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors .
    Talaporfin
  • HY-157470
    PPO-IN-6

    		Others Cancer
    PPO-IN-6 is a protoporphyrinogen oxidase (PPO) inhibitor that blocks the production of heme and chlorophyll. Pop-in-6 can be used IN the detection and research of cancer and other diseases .
    PPO-IN-6
  • HY-13547
    ADPM06

    		Apoptosis Cancer
    ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis .
    ADPM06
  • HY-168261
    CQ-ER

    		Ferroptosis Cancer
    CQ-ER is a Coumarin (HY-N0709)-Quinazolinone based endoplasmic reticulum (ER)-targeted photosensitizer. CQ-ER can cause ferroptosis, thereby enhancing photodynamic therapy (PDT) .
    CQ-ER
  • HY-168097
    Ferroptosis inducer-6

    		Ferroptosis Reactive Oxygen Species Cancer
    Ferroptosis inducer 6 (6d) is a ferroptosis inducer with high potency for type I/-II photodynamic therapy by inducing ROS generation, oxidative stress and mitochondrial damage. Ferroptosis inducer 6 has anti-tumor activity .
    Ferroptosis inducer-6
  • HY-157051
    [Ru(DIP)2TAP]Cl2

    		Others Cancer
    [Ru(DIP)2TAP]Cl2, Ruthenium(II) polypyridyl compound, is a photosensitizer. [Ru(DIP)2TAP]Cl2 can be used for the research of photodynamic therapy (PDT) .
    [Ru(DIP)2TAP]Cl2
  • HY-151940
    Mal-Pc

    		Reactive Oxygen Species Cancer
    Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells .
    Mal-Pc
  • HY-D1063
    IR-780

    		Fluorescent Dye Cancer
    IR780 is a prototypic NIR heptamethine cyanine agent, with a high molar extinction coefficient. The maximum excitation wavelength of IR780 was 777-780 nm, and the maximum emission wavelength was 798-823 nm. IR780 can be used in cancer PTT/PDT and imaging .
    IR-780
  • HY-19873
    SL-052

    		Others Cancer
    SL-052 is a hypocrellin-based photosensitizer that has recently shown promising results in clinical and preclinical testing for cancer photodynamic therapy (PDT). SL-052 is encapsulated in biodegradable polylactic-co-glycolic acid (PLGA) polymer nanoparticles optimized using single emulsion solvent evaporation technology. The SL-052-PLGA nanoparticles were more effective in PDT treatment of subcutaneous SCCVII squamous cell carcinoma compared to polyvinylpyrrolidone (PVP)-based and standard liposomal SL-052 formulations. A longer time interval between drug injection and tumor illumination can improve tumor cure rates, and SL-052-PLGA nanoparticles showed the best therapeutic effect among all SL-052 formulations.
    SL-052
  • HY-N6743
    Cercosporin

    CGP049090

    		 PKC Cancer
    Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations . Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM .
    Cercosporin
  • HY-128973
    Pyropheophorbide-a

    		Reactive Oxygen Species Cancer
    Pyropheophorbide-a (Ppa) is a photosensitizer used in photodynamic therapy (PDT) for tumors. Pyropheophorbide-a exhibits phototoxic effects on tumor cells, such as cervical cancer cells, and also has anti-lipogenesis activity. Pyropheophorbide-a shows potential for research in the fields of cancer and age-related macular degeneration (AMD). Pyropheophorbide-a derivatives also demonstrate inhibitory activity against tumor cells .
    Pyropheophorbide-a
  • HY-N2575
    Hypocrellin A
    1 Publications Verification

    		 PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis Infection Metabolic Disease Cancer
    Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml) .
    Hypocrellin A
  • HY-W130236
    Methylene Violet 3RAX

    		Cholinesterase (ChE) Cancer
    Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .
    Methylene Violet 3RAX
  • HY-151486
    GLUT1-IN-1

    		GLUT Cancer
    GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer .
    GLUT1-IN-1
  • HY-157053
    [Ru(dppn)2phen](PF6)2

    		Others Cancer
    [Ru(dppn)2phen](PF6)2 (compound 4) is a polypyridylruthenium compound used in photodynamic therapy (PDT). [Ru(dppn)2phen](PF6)2 is normally nontoxic under dark conditions and induces mitochondrial respiratory damage upon light exposure. [Ru(dppn)2phen](PF6)2 exhibits high levels of singlet oxygen quantum yield and phototoxicity against cancer cells .
    [Ru(dppn)2phen](PF6)2
  • HY-161668
    Ru-Poma

    		Ligands for E3 Ligase Ferroptosis Cancer
    Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively .
    Ru-Poma
  • HY-162944
    NA-Ir

    		Ferroptosis Mitochondrial Metabolism STING Autophagy Cancer
    NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels .
    NA-Ir
  • HY-163691
    Antitumor agent-163

    		Carbonic Anhydrase Cancer
    Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .
    Antitumor agent-163
  • HY-147690
    Photosensitizer-2

    		Others Cancer
    Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor activity against HeLa cells, with IC50 values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation), respectively .
    Photosensitizer-2

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: