Cercosporin (Synonyms: CGP049090)

Cat. No.: HY-N6743 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM.

For research use only. We do not sell to patients.

Cercosporin Chemical Structure

CAS No. : 35082-49-6

Size	Price	Stock	Quantity
1 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PKC Isoform Specific Products:

View All Isoforms

PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations^[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM^[2].

IC₅₀ & Target

IC50: 0.6-1.3 μM (PKC)^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	10.8 μM Compound: 5	Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
KB	IC₅₀	7.1 μM Compound: 5	Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
SK-MEL	IC₅₀	3.6 μM Compound: 5	Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
SK-OV-3	IC₅₀	3.7 μM Compound: 5	Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method	[PMID: 22530813]

In Vitro

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD₅₀ value for the T98G cells (0.14 J cm²) is much less than the LD₅₀ value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm², respectively)^[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
Concentration:	0 μM, 1 μM, 2 μM, 3 μM
Incubation Time:	24 hours
Result:	Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

Molecular Weight

534.51

Formula

C₂₉H₂₆O₁₀

CAS No.

35082-49-6

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C=C(C(C2=C34)=C5C1=C(O)C(OC)=C(C[C@H](O)C)C5=C4C(C[C@H](O)C)=C6OC)OCOC2=CC(O)=C3C6=O

Structure Classification

Others

Initial Source

Microorganisms

Pseudocercosporella capsellae

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 10 mg/mL (18.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8709 mL	9.3544 mL	18.7087 mL
5 mM	0.3742 mL	1.8709 mL	3.7417 mL
10 mM	0.1871 mL	0.9354 mL	1.8709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (284 KB) SDS (251 KB)

COA (264 KB)

Handling Instructions (2659 KB)

References

[1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396. [Content Brief]

[2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8709 mL	9.3544 mL	18.7087 mL	46.7718 mL
	5 mM	0.3742 mL	1.8709 mL	3.7417 mL	9.3544 mL
	10 mM	0.1871 mL	0.9354 mL	1.8709 mL	4.6772 mL
	15 mM	0.1247 mL	0.6236 mL	1.2472 mL	3.1181 mL

Cercosporin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cercosporin35082-49-6CGP049090CGP 049090CGP-049090PKCProtein kinase CInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Cercosporin (Synonyms: CGP049090)

Customer Review

Cercosporin Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PKC Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Cercosporin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cercosporin Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report