2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Antitumor agent-163

Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model.

For research use only. We do not sell to patients.

Antitumor agent-163 Chemical Structure

Antitumor agent-163 Chemical Structure

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Antitumor agent-163 Related Antibodies

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Description

Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model[1].

Molecular Weight

825.26

Formula

C27H32BF2I2N5O4S
SMILES

O=S(C1=CC=C(C(NCCCCCCNC(CCC2=[N+](C(C=C2I)=C3)[B-](F)(F)N4C3=C(C)C(I)=C4C)=O)=O)C=C1)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-163 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-163Antitumor agent163Antitumor agent 163Carbonic AnhydraseCarbonate dehydrataseA549U87MGphotosensitizerInhibitorinhibitorinhibit

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