2. Apoptosis
  3. Apoptosis
  4. ADPM06

ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis.

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ADPM06 Chemical Structure

ADPM06 Chemical Structure

CAS No. : 490035-90-0

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Based on 1 publication(s) in Google Scholar

ADPM06 Related Antibodies

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Description

ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 50 μM
Compound: 1; ADPM06
Dark toxicity in human HeLa cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human HeLa cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
HeLa IC50
0.13 μM
Compound: 1; ADPM06
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
MCF7 IC50
> 50 μM
Compound: 1; ADPM06
Dark toxicity in human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
MCF7 IC50
0.15 μM
Compound: 1; ADPM06
Phototoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human MCF7 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
SW480 IC50
> 50 μM
Compound: 1; ADPM06
Dark toxicity in human SW480 cells assessed as reduction in cell viability after 3 hrs by MTT assay
Dark toxicity in human SW480 cells assessed as reduction in cell viability after 3 hrs by MTT assay
[PMID: 32787080]
SW480 IC50
0.16 μM
Compound: 1; ADPM06
Phototoxicity against human SW480 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
Phototoxicity against human SW480 cells assessed as reduction in cell viability preincubated for 3 hrs followed by 54 J/cm2 light irradiation and measured after 24 hrs by MTT assay
[PMID: 32787080]
In Vitro

The efficacy of ADPM01 is completely ablated at a 1% oxygen level in Hela and MRC5 cell lines. ADPM06 displays only a partial reduction in light-induced activity in hypoxic as compared to normoxic conditions[1].
ADPM06-PDT induces ER stress and unfolded protein response[2].
ADPM06-PDT induces apoptosis and involves caspase enzymatic activity[2].
Following ADPM06-PDT, a rapid processing of XBP1 mRNA occurs resulting in the removal of an intron from the mRNA in a spliceosome-independent manner, a post-transcriptional modification catalyzed by the action of activated inositol-requiring protein 1 (IRE1)[2].
ADPM06-PDT-induced apoptosis involves the generation of ROS[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADPM06 Related Antibodies

Cell Viability Assay[1]

Cell Line: Hela and MRC5 cell lines.
Concentration: 1 nM - 100μM.
Incubation Time: 24 h.
Result: Retained considerable efficacy, with EC50 values of 1.5 and 1.6 × 10−6 M for HeLa and MRC5 cells, respectively.
In Vivo

ADPM06-PDT has revealed an initiation of apoptosis in vivo, as well as induction of an ER stress response[2].
ADPM06-PDT is well tolerated in vivo and elicits impressive complete response rates in various models of cancer when a short drug-light interval is applied[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb C nu/nu mice[2].
Dosage: 2 mg/kg in 0.3 mL solution via the lateral tail vein.
Administration: IV.
Result: Revealed a rapid reduction in tumor-specific luciferase activity as early as 1-hr post-PDT, with levels decreasing further 4-hr post-PDT.
Molecular Weight

715.19

Formula

C34H24BBr2F2N3O2
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

[F-][B+3]1([N]2=C(C3=CC=C(OC)C=C3)C(Br)=C(C4=CC=CC=C4)C2=NC5=C(C(Br)=C([N-]51)C6=CC=C(OC)C=C6)C7=CC=CC=C7)[F-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% Cremophor EL in PBS

    Solubility: 2 mg/mL (2.80 mM); Suspended solution; Need ultrasonic

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Purity & Documentation
References
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ADPM06 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADPM06490035-90-0ADPM 06ADPM-06ApoptosisERstressunfoldedproteinresponseUPRInhibitorinhibitorinhibit

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