Talaporfin (Synonyms: ME2906 free acid; Mono-L-aspartyl chlorin e6 free acid; NPe6 free acid)

Cat. No.: HY-16477A: FAQs
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Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors.

For research use only. We do not sell to patients.

Talaporfin Chemical Structure

CAS No. : 110230-98-3

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Other In-stock Forms of Talaporfin:

Talaporfin sodium

Other Forms of Talaporfin:

Talaporfin sodium In-stock

3 Publications Citing Use of MCE Talaporfin

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	181 μM Compound: Talaporfin	Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay	[PMID: 33744687]
A549	IC₅₀	256 μM Compound: Talaporfin	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
A549	IC₅₀	6.21 μM Compound: Talaporfin	Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay	[PMID: 33744687]
A549	IC₅₀	8.73 μM Compound: Talaporfin	Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]
B16-F10	IC₅₀	14 μM Compound: Talaporfin	Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]
B16-F10	IC₅₀	303 μM Compound: Talaporfin	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
HCT-116	IC₅₀	2.95 μM Compound: Talaporfin	Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay	[PMID: 33744687]
HCT-116	IC₅₀	50.72 μM Compound: Talaporfin	Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay	[PMID: 33744687]
HeLa	IC₅₀	> 300 μM Compound: Talaporfin	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
HeLa	IC₅₀	5.92 μM Compound: Talaporfin	Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]

Molecular Weight

711.76

Formula

C₃₈H₄₁N₅O₉

CAS No.

110230-98-3

SMILES

O=C(O)C[C@@H](C(O)=O)NC(C/C1=C2[C@@H](CCC(O)=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C(N/3)=C/C(C(C)=C/4CC)=NC4=C/C5=C(C)C(C(O)=O)=C1N5)=N\2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors

Talaporfin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talaporfin110230-98-3ME2906Mono-L-aspartyl chlorin e6NPe6ME 2906ME-2906NPe 6NPe-6OthersInhibitorinhibitorinhibit

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