2. Membrane Transporter/Ion Channel
  3. GLUT
  4. GLUT1-IN-1

GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer.

For research use only. We do not sell to patients.

GLUT1-IN-1 Chemical Structure

GLUT1-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

GLUT1-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All GLUT Isoform Specific Products:

View All Isoforms
GLUT1 GLUT2 GLUT3 GLUT4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer[1].

IC50 & Target[1]

GLUT1

 

In Vitro

GLUT1-IN-1(compound 8) (0-100 μM; 1 h) exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC50 values of 5.49, 11.14, and 8.73 μM, respectively (Under light irradiation) [1].
GLUT1-IN-1 (0-100 μM; 1 h) possesses sufficient photosensitizing ability to exhibit significant cytotoxicity and that the glucose conjugation contributes to the suppression of the cytotoxicity of I2BODIPY[1].
GLUT1-IN-1 (8 μM, 10 μM; 1 h) selectively interacts with GLUT1 and oxidizes it under light irradiation, resulting in the conversion of GLUT1 into a derivative that is undetectable by immunoblotting analysis[1].
GLUT1-IN-1(1 h) has a GLUT1-specific inactivation ability and causes lightinduced cytotoxicity by modulating the EGFR/MAPK signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GLUT1-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 0-100 μM
Incubation Time: 1 h
Result: Exhibited a concentration-dependent cytotoxicity against these cancer cell lines under light irradiation.

Western Blot Analysis[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Not detected GLUT1in cell lines treated with 10 uM under light irradiation.
Reduced the levels of epidermal growth factor receptor tyrosine kinase (EGFR), phospho-ERK (Y204), and GLUT1 without affecting ERK, atubulin, and PCNA protein levels.

Immunofluorescence[1]

Cell Line: HeLa, A549 and HepG2 cells
Concentration: 8, 10 μM
Incubation Time: 1 h
Result: Observed a reduction in the intensity of the fluorescent signals due to glucose transporter 1 (GLUT1).
Molecular Weight

830.17

Formula

C25H31BF2I2N6O7
SMILES

OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OCCN2N=NC(CNC(CCC3=[N]4C(C=C3I)=CC5=C(C(I)=C(N5B4(F)F)C)C)=O)=C2)O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GLUT1-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLUT1-IN-1GLUTGlucose transporterChromophore-assisted light inactivation (CALI)photodynamic therapy (PDT)glucose transporter 1 (GLUT1)cancer cellsphotosensitizersanhydrase II (CAII)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GLUT1-IN-1
Cat. No.:
HY-151486
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.