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Prostaglandin E synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (2) PGE synthase (14) Prostaglandin Receptor (2) COX (2) Lipoxygenase (3) NF-κB (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (16) Metabolic Disease (1) Neurological Disease (1)

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Targets Recommended: PGE synthase Prostaglandin Receptor Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase GSK-3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147416

Vipoglanstat BI 1029539; GS-248; OX-MPI	PGE synthase	Infection Cancer
Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .

HY-125415

PF-4693627	PGE synthase	Inflammation/Immunology
PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .

HY-19622

PF-9184	PGE synthase	Inflammation/Immunology
PF-9184 is a potent and highly selective inhibitor of human *microsomal prostaglandin* E synthase-1 (mPGES-1), with an IC₅₀** of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE₂ synthesis in vitro .

HY-162387

UK4b	PGE synthase	Cardiovascular Disease Inflammation/Immunology Cancer
UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice .

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-N3535

Canniprene	Prostaglandin Receptor Lipoxygenase	Inflammation/Immunology
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

HY-169858

Prostaglandin E2 Inhibitor 3	PGE synthase	Inflammation/Immunology
Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀ = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice .

HY-156612

Friluglanstat	PGE synthase	Inflammation/Immunology
Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity .

HY-106119

Camonagrel	Prostaglandin Receptor	Infection
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. Camonagrel is a potent thromboxane synthase inhibitor .

HY-13475

mPGES1-IN-8	PGE synthase	Inflammation/Immunology
mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor .

HY-139589

Zaloglanstat ISC-27864; GRC-27864	PGE synthase	Neurological Disease Inflammation/Immunology
Zaloglanstat (ISC-27864) is a selective and orally active inhibitor of *microsomal prostaglandin* E synthase-1 (mPGES-1) with an IC₅₀ of 5 nM. Zaloglanstat inhibits PGE₂** release of IC₅₀ at 161 nM and 154 nM in whole blood of pigs and dogs, respectively. Zaloglanstat can be used in studies of asthma, osteoarthritis and neurodegenerative diseases .

HY-122178

5-trans U-44069	PGE synthase	Cardiovascular Disease
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits **prostaglandin E2 synthase** activity .

HY-100864

mPGES1-IN-3	PGE synthase	Inflammation/Immunology
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC₅₀: 8 nM), cell (A549 IC₅₀: 16.24 nM) and human whole blood potency (IC₅₀: 249.9 nM) .

HY-N9814

Shanciol B	NO Synthase	Inflammation/Immunology
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-126898

5-LO/mPGES1-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells .

HY-N6966

Ethyl Caffeate 1 Publications Verification	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-N6966A

Ethyl trans-caffeate	Others	Inflammation/Immunology
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-131626

1a,1b-Dihomo prostaglandin E2 1a,1b-Dihomo PGE2	COX	Metabolic Disease
1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.

HY-N8936

Narchinol B	Others	Inflammation/Immunology
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

Canniprene	Structural Classification Monophenols Cannabis sativa L Classification of Application Fields Source classification Phenols Plants Moraceae Inflammation/Immunology Disease Research Fields	Prostaglandin Receptor Lipoxygenase
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

Ethyl Caffeate 1 Publications Verification	Structural Classification Classification of Application Fields Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Inflammation/Immunology Disease Research Fields Cancer	NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

Ethyl trans-caffeate	Source classification Lactuca perennis Plants Compositae	Others
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

Shanciol B	Pholidota imbricata Hook. Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	NO Synthase
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

Narchinol B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic Prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3131), targeting p23, with a predicted molecular weight of 19 kDa (observed band size: 23 kDa). p23 Antibody (YA3131) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P81996

	Prostaglandin E Synthase Antibody (YA1741) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a biotin-conjugated non-conjugated IgG antibody, targeting Prostaglandin E Synthase, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). Prostaglandin E Synthase Antibody (YA1741) can be used for WB experiment in human, mouse, rat background.

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Prostaglandin E synthase

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