2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Lipoxygenase
  4. Canniprene

Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins.

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Canniprene Chemical Structure

Canniprene Chemical Structure

CAS No. : 70677-47-3

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Based on 1 publication(s) in Google Scholar

Canniprene Related Antibodies

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Description

Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; IC50=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins[1].

IC50 & Target[1]

5-LO

0.4 μM (IC50)

PGE2

10 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
10 μM
Compound: 1
Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cells microsomal membranes assessed as reduction in conversion of PGH2 to PGE2 pre-incubated for 15 mins followed by PGH2 substrate addition measured after 1 min by RP-HPLC method
Inhibition of mPGES-1 in interleukin-1 beta-stimulated human A549 cells microsomal membranes assessed as reduction in conversion of PGH2 to PGE2 pre-incubated for 15 mins followed by PGH2 substrate addition measured after 1 min by RP-HPLC method
[PMID: 28165233]
Molecular Weight

342.43

Formula

C21H26O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(OC)C=CC(CCC2=CC(OC)=CC(O)=C2)=C1C/C=C(C)\C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Canniprene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canniprene70677-47-3Prostaglandin ReceptorLipoxygenaseLOXCannabis sativainflammatory eicosanoidsprostaglandinspotentcyclooxygenase/microsomalInhibitorinhibitorinhibit

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