YS121

Cat. No.: HY-111140 Purity: 99.74%: FAQs
Data Sheet SDS COA Handling Instructions

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YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells.

For research use only. We do not sell to patients.

YS121 Chemical Structure

CAS No. : 916482-17-2

Size	Price	Stock	Quantity
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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5-LOX 12-LOX 15-LOX

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	12 μM Compound: 2d	Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay	[PMID: 19053751]
A549	IC₅₀	3.9 μM Compound: 2d	Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay	[PMID: 19053751]
COS-7	EC₅₀	1 μM Compound: 3	Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay Agonist activity at wild-type human PPARalpha LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay	[PMID: 25022880]
COS-7	IC₅₀	1 μM Compound: 2	Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay Activation of human PPARalpha ligand binding domain expressed in COS7 cells by luciferase reporter gene assay	[PMID: 25037914]
COS-7	EC₅₀	3.6 μM Compound: 3	Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay Agonist activity at human PPARgamma LBD expressed in COS7 cells after 12 hrs by Dual-Glo luciferase assay	[PMID: 25022880]
COS-7	EC₅₀	3.6 μM Compound: 2	Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay Transactivation of human PPARgamma LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay	[PMID: 20307981]
COS-7	IC₅₀	3.6 μM Compound: 2	Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assay	[PMID: 25037914]

Molecular Weight

407.96

Formula

C₂₀H₂₆ClN₃O₂S

CAS No.

916482-17-2

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCC(SC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (306.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4512 mL	12.2561 mL	24.5122 mL
5 mM	0.4902 mL	2.4512 mL	4.9024 mL
10 mM	0.2451 mL	1.2256 mL	2.4512 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (245 KB) HNMR (276 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Hui-Hua Chang, et al. Identification and development of mPGES-1 inhibitors: where we are at?. Future Med Chem. 2011 Nov;3(15):1909-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4512 mL	12.2561 mL	24.5122 mL	61.2805 mL
	5 mM	0.4902 mL	2.4512 mL	4.9024 mL	12.2561 mL
	10 mM	0.2451 mL	1.2256 mL	2.4512 mL	6.1281 mL
	15 mM	0.1634 mL	0.8171 mL	1.6341 mL	4.0854 mL
	20 mM	0.1226 mL	0.6128 mL	1.2256 mL	3.0640 mL
	25 mM	0.0980 mL	0.4902 mL	0.9805 mL	2.4512 mL
	30 mM	0.0817 mL	0.4085 mL	0.8171 mL	2.0427 mL
	40 mM	0.0613 mL	0.3064 mL	0.6128 mL	1.5320 mL
	50 mM	0.0490 mL	0.2451 mL	0.4902 mL	1.2256 mL
	60 mM	0.0409 mL	0.2043 mL	0.4085 mL	1.0213 mL
	80 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7660 mL
	100 mM	0.0245 mL	0.1226 mL	0.2451 mL	0.6128 mL

YS121 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YS121916482-17-2YS 121YS-121PGE synthaseLipoxygenaseProstaglandin E synthaseLOXmicrosomal prostaglandin E2 synthasemPGES-15-lipoxygenase5-LOXPGE2Inhibitorinhibitorinhibit

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YS121

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YS121 Related Antibodies

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Complete Stock Solution Preparation Table

YS121 Related Classifications

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