2. Immunology/Inflammation
  3. PGE synthase
  4. UK4b

UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice.

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UK4b Chemical Structure

UK4b Chemical Structure

CAS No. : 2171000-87-4

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Based on 1 publication(s) in Google Scholar

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Description

UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1].

In Vivo

UK4b (10-20 mg/kg; s.c.; twice daily for 22 consecutive days) can block the further growth of abdominal aortic aneurysms (AAA) in an ApoE−/− angiotensin (Ang) II (1000 ng/kg/min; infusion for 28 consecutive days) -induced mouse model of AAA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

404.89

Formula

C21H25ClN2O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

ClC(C=C(/C=C1C(NC(NC/1=O)=O)=O)C=C2)=C2OCCCCC3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4698 mL 12.3490 mL 24.6981 mL
5 mM 0.4940 mL 2.4698 mL 4.9396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4698 mL 12.3490 mL 24.6981 mL 61.7452 mL
5 mM 0.4940 mL 2.4698 mL 4.9396 mL 12.3490 mL
10 mM 0.2470 mL 1.2349 mL 2.4698 mL 6.1745 mL
15 mM 0.1647 mL 0.8233 mL 1.6465 mL 4.1163 mL
20 mM 0.1235 mL 0.6175 mL 1.2349 mL 3.0873 mL
25 mM 0.0988 mL 0.4940 mL 0.9879 mL 2.4698 mL
30 mM 0.0823 mL 0.4116 mL 0.8233 mL 2.0582 mL
40 mM 0.0617 mL 0.3087 mL 0.6175 mL 1.5436 mL
50 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2349 mL
60 mM 0.0412 mL 0.2058 mL 0.4116 mL 1.0291 mL
80 mM 0.0309 mL 0.1544 mL 0.3087 mL 0.7718 mL
100 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6175 mL
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UK4b Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK4b2171000-87-4PGE synthaseProstaglandin E synthaseAbdominal aortic aneurysm (AAA)anti-inflammatoryease painInhibitorinhibitorinhibit

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