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RD-23

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168867
    RD-23

    		PROTACs RET Cancer
    RD-23 is an orally active and selective RET PROTAC degrader. RD-23 promotes ubiquitination and degradation of RET G810C mutation, with a DC50 value of 11.7 nM. RD-23 inhibits the activation of downstream Shc signaling and induces Apoptosis. RD-23 can be used for the research of RET-related cancers (Pink: RET ligand-2 (HY-168868); Blue: E3 ligase CRBN ligand; Black: linker) .
    RD-23
  • HY-168868
    RET ligand-2

    		RET Ligands for Target Protein for PROTAC Cancer
    RET ligand-2 is a selective RET inhibitor. RET ligand-2 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC RET degraders with antitumor activity. RET ligand-2 can be used for the synthesis of RD-23 (HY-168867) .
    RET ligand-2

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