2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs RET
  4. RD-23

RD-23 is an orally active and selective RET PROTAC degrader. RD-23 promotes ubiquitination and degradation of RETG810C mutation, with a DC50 value of 11.7 nM. RD-23 inhibits the activation of downstream Shc signaling and induces Apoptosis. RD-23 can be used for the research of RET-related cancers (Pink: RET ligand-2 (HY-168868); Blue: E3 ligase CRBN ligand; Black: linker).

For research use only. We do not sell to patients.

RD-23 Chemical Structure

RD-23 Chemical Structure

CAS No. : 3053537-06-4

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RD-23 Related Antibodies

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Description

RD-23 is an orally active and selective RET PROTAC degrader. RD-23 promotes ubiquitination and degradation of RETG810C mutation, with a DC50 value of 11.7 nM. RD-23 inhibits the activation of downstream Shc signaling and induces Apoptosis. RD-23 can be used for the research of RET-related cancers (Pink: RET ligand-2 (HY-168868); Blue: E3 ligase CRBN ligand; Black: linker)[1].

Molecular Weight

913.08

Formula

C52H56N12O4
CAS No.
SMILES

N#CC1=C2C(C3=CC=C(N=C3)N4CC5CC(C4)N5CC6=CC=C(N=C6)OC)=CC(N7CCC(CC7)N8CCN(CC8)CCCC#CC9=CC=CC%10=C9CN(C%10=O)C(C(N%11)=O)CCC%11=O)=CN2N=C1
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Room temperature in continental US; may vary elsewhere.
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RD-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RD-233053537-06-4RD23RD 23PROTACsRETAntitumorAntiproliferativeXenograftBa/F3 cellBALB/cnu/nu.Inhibitorinhibitorinhibit

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