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Results for "

RIOK

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

3

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112158
    NSC139021
    1 Publications Verification

    ERGi-USU

    		 Others Cancer
    NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC50s???of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling .
    NSC139021
  • HY-147655
    CQ211

    		Ser/Thr Kinase Cancer
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines .
    CQ211
  • HY-156465
    RIOK2-IN-2

    		Ser/Thr Kinase Cancer
    RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC50 values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively .
    RIOK2-IN-2
  • HY-156792
    RIOK2-IN-1

    		Ser/Thr Kinase Cancer
    RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression .
    RIOK2-IN-1
  • HY-RS11988
    RIOK1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RIOK1 Human Pre-designed siRNA Set A contains three designed siRNAs for RIOK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RIOK1 Human Pre-designed siRNA Set A
    RIOK1 Human Pre-designed siRNA Set A
  • HY-RS11989
    RIOK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RIOK2 Human Pre-designed siRNA Set A contains three designed siRNAs for RIOK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RIOK2 Human Pre-designed siRNA Set A
    RIOK2 Human Pre-designed siRNA Set A
  • HY-RS11990
    RIOK3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RIOK3 Human Pre-designed siRNA Set A contains three designed siRNAs for RIOK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RIOK3 Human Pre-designed siRNA Set A
    RIOK3 Human Pre-designed siRNA Set A
  • HY-170574
    CQ627

    		Molecular Glues Ser/Thr Kinase Apoptosis Cancer
    CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model .
    CQ627

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