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SARS-CoV-2 Mpro inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (61) Antibiotic (1) Bacterial (1) Cathepsin (3) Ceramidase (2) COX (1) DNA/RNA Synthesis (1) FAAH (2) Fungal (1) Glutathione Peroxidase (2) HCV (1) HCV Protease (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Nucleoside Antimetabolite/Analog (2) PROTACs (2) Virus Protease (14)
By Research Areas:	Cancer (3) Infection (61) Inflammation/Immunology (6)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: SARS-CoV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163742

SARS-CoV-2 Mpro-IN-22	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-22 (compound 4), a hydrolysable tannin, is a potent **SARS-CoV-2 main protease (Mpro)** inhibitor with an IC₅₀ value of 1.2 µg/mL. SARS-CoV-2 Mpro-IN-22 does not show any significant cytotoxic activity against A549 and HUVEC cell lines .

HY-155143

CDD-1733	SARS-CoV	Infection
CDD-1733 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 12 nM. CDD-1733 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-155142

CDD-1819	SARS-CoV	Infection
CDD-1819 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 5 nM. CDD-1819 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-155144

CDD-1845	SARS-CoV	Infection
CDD-1845 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 3 nM. CDD-1845 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-158687

SARS-CoV-2 Mpro-IN-18	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-18 (compound 84) is a potent **SARS-CoV-2 Mpro** inhibitor with the IC₅₀ of 3.23 nM. SARS-CoV-2 Mpro-IN-18 can be used for study of anti-SARS-CoV-2 agent .

HY-169260

SARS-CoV-2 Mpro-IN-27	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-27 (Compound 4h) is a potent **SARS-CoV-2 Mpro** inhibitor .

HY-161777

SARS-CoV-2 Mpro-IN-23	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-23 (Compound 2) is an inhibitor for SARS-CoV-2 main protease (Mpro), which inhibits wildtype Mpro and mutant Mpro variants, with IC₅₀ of 0.057-0.92 μM. SARS-CoV-2 Mpro-IN-23 inhibits the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), suppresses the viral replication of Mpro wildtype and Mpro mutants with EC₅₀ of 0.02-0.52 μM .

HY-163627

SARS-CoV-2 Mpro-IN-19	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-19 (compound MPI94) is a **SARS-CoV-2 MPro** inhibitor with the IC₅₀ of 0.096 μM. SARS-CoV-2 Mpro-IN-19 can be used for study of COVID-19 .

HY-158347

SARS-CoV-2 Mpro-IN-15	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-15 (8E) is a **SARS-CoV-2 Mpro** inhibitor, with an IC₅₀ of 0.606 µM .

HY-158422

SARS-CoV-2 Mpro-IN-16	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-16 (compound 5J) is a **SARS-CoV-2 Mpro** inhibitor, and inhibits HEK293 cells growth .

HY-156459

SARS-CoV-2 Mpro-IN-12	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-12 (compound D026) is a **SARS-CoV-2 main protease (Mpro)** inhibitor with antiviral activities .

HY-163186

SARS-CoV-2 Mpro-IN-13	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-13 (compound 20j) is a covalent **SARS-CoV-2 Protease Mpro** inhibitor with an IC₅₀ value of 19.0 nM. SARS-CoV-2 Mpro-IN-13 processes antiviral activity with an EC₅₀ value of 138.1 nM .

HY-163211

SARS-CoV-2 Mpro-IN-14	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-14 (Compound 19) is an inhibitor of **SARS-CoV-2 Mpro with an IC₅₀** of 0.044 μM. SARS-CoV-2 Mpro-IN-14 exhibits water solubility, has no cytotoxicity, and can be used in the study of COVID-19 .

HY-163628

SARS-CoV-2 Mpro-IN-20	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-20 (compound MPI100) is a *SARS-CoV-2* main protease inhibitor. SARS-CoV-2 Mpro-IN-20 shows antiviral activity with the EC₅₀ of 3.4 μM .

HY-158440

SARS-CoV-2 Mpro-IN-17	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-17 (compound S5-28) is an orally active and noncovalent **SARS-CoV-2 Mpro** inhibitor with the EC₅₀ of 1.35 μM. SARS-CoV-2 Mpro-IN-17 can be used for study of COVID-19 .

HY-151900

SARS-CoV-2 Mpro-IN-4	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (M ^Pro) and Cathepsin L (CatL), with IC₅₀s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 8.2 nM .

HY-151901

SARS-CoV-2 Mpro-IN-5	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (M ^Pro) and Cathepsin L (CatL), with IC₅₀s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 14.7 nM .

HY-169055

SARS-CoV-2 Mpro-IN-25	Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-25 (Compound 3a) is a SARS-CoV-2 protease inhibitor with an IC₅₀ value of 0.26 μM. SARS-CoV-2 Mpro-IN-25 exhibits antiviral activity and can be used in pneumonia-related research .

HY-161722

SARS-CoV-2 Mpro-IN-21	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-21 (compound A8) is a potent *SARS-CoV-2* and OVID-19 Main Protease M ^Pro inhibitor. SARS-CoV-2 Mpro-IN-21 shows excellent antioxidant activity in DPPH assay with an IC₅₀ of 0.36 mg/mL. SARS-CoV-2 Mpro-IN-21 also exhibits better antibacterial potency against Klebsiella with an IC₅₀ of 1.19 mg/mL .

HY-152108

SARS-CoV-2 Mpro-IN-6	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 M ^pro inhibitor with an IC₅₀ of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3 .

HY-155654

SARS-CoV-2 Mpro-IN-10	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-10 (27h) is a potent M ^pro inhibitor with IC₅₀ value and EC₅₀ values of 10.9 nM and 43.6 nM, respectively. SARS-CoV-2 Mpro-IN-10 can be used for the research of SARS-CoV-2 virus .

HY-144464

SARS-CoV-2 Mpro-IN-1	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible inhibitor of **SARS-CoV-2 main protease (Mpro), with an IC₅₀** of 116 nM .

HY-135860

SARS-CoV-2-IN-1	Virus Protease SARS-CoV	Infection
SARS-CoV-2-IN-1 is a potent *Mpro* inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC₅₀s of 0.67, 0.90 and 0.58 μM, respectively .

HY-161837

SARS-CoV-2 Mpro-IN-24	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-24 (Compound X77) is a inhibitor of **SARS-CoV-2 Mpro (IC₅₀*=2.8 μM) and also a non-covalent inhibitor* of SARS-CoV Mpro (IC₅₀=3.4 μM) .

HY-151608

SARS-CoV-2 Mpro-IN-3	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-3 is a potent M ^pro inhibitor with an IC₅₀ value of ﹥5 μM. SARS-CoV-2 Mpro-IN-3 can be used in research of COVID-19 .

HY-149606

TKB245	SARS-CoV	Infection
TKB245 is a highly potent **SARS-CoV-2 Mpro** inhibitor that effectively blocks SARS-CoV-2 replication in VeroE6 cells .

HY-N11896A

10-Hydroxyaloin A	SARS-CoV	Infection Inflammation/Immunology
10-10-Hydroxyaloin A is potent *SARS-CoV-2* inhibitor. 10-Hydroxyaloin A exhibits significant efficacy to bind SARS-Cov-2 M_pro active site .

HY-155527

SARS-CoV-2 Mpro-IN-9	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent *SARS-CoV-2* M ^pro inhibitor (IC₅₀=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC₅₀=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC₅₀>50 μM) .

HY-151482

SARS-CoV-2 Mpro-IN-2	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent M ^pro inhibitor (IC₅₀=0.40 μM) with good anti-SARS-CoV-2 activity (EC₅₀=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies .

HY-153533

GRL-1720	SARS-CoV	Infection
GRL-1720 is a potent **SARS-CoV-2 Mpro** inhibitor with an EC₅₀ value of 15 µM. GRL-1720 shows anti-SARS-CoV2 activity .

HY-157144

SARS-CoV-2-IN-68	SARS-CoV	Infection
SARS-CoV-2-IN-68 (compound 6C) is a covalent **SARS-CoV-2 PLpro/Mpro** inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro .

HY-136149A

Mpro inhibitor N3 hemihydrate	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 hemihydrate is a potent inhibitor of **SARS-CoV-2 Mpro** with an EC₅₀ of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC₅₀ of 4.0 μM, 8.8 μM, and 2.7 μM, respectively .

HY-126085

(±)-Alliin 2 Publications Verification (±)-L-Alliin	SARS-CoV	Infection
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of **SARS-CoV-2 (M_pro)** .

HY-W348072

SARS-CoV-2-IN-59	SARS-CoV	Infection
SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule inhibitor of SARS-CoV-2 that targets the main protease (Mpro) of the coronavirus. SARS-CoV-2-IN-59 has a strong interaction with residues on Mpro (Met 165, Gln 166, Met 165, His 41, Gln 189) .

HY-153533A

GRL-1720 TFA	SARS-CoV	Infection
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 value of 15 μM. GRL-1720 TFA shows anti-SARS-CoV2 activity .

HY-151988

SARS-CoV-2-IN-36	SARS-CoV	Infection
SARS-CoV-2-IN-36 is a potent **SARS-CoV-2 Mpro (SARS-CoV*) inhibitor* with an IC₅₀ of 2.37 μM and a K_d of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells .

HY-156734

D-4-77	SARS-CoV Virus Protease	Infection
D-4-77 is a potent inhibitor of **SARS-CoV-2 Mpro with an IC₅₀ value of 0.95 μM. D-4-77 has antiviral active with an EC₅₀** value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response .

HY-155056

SARS-CoV-2 Mpro-IN-7	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-7 (compound 6g) is a potent inhibitor of M ^pro-SARS-CoV-2 (IC₅₀=8.8 μM, CC₅₀=10 μM) .

HY-151990

SARS-CoV-2/MERS Mpro-IN-1	SARS-CoV	Infection
SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent *SARS-CoV-2* and MERS main protease inhibitor with IC₅₀ values of 0.10, 0.06 µM, respectively .

HY-151991

SARS-CoV-2/MERS Mpro-IN-2	SARS-CoV	Infection
SARS-CoV-2/MERS Mpro-IN-2 (compound 9d) is a potent *SARS-CoV-2* and MERS main protease inhibitor with IC₅₀ values of 0.21, 0.07 µM, respectively .

HY-162464

MPD2	PROTACs SARS-CoV	Infection
MPD2 is a Cereblon-binding ligand-based PROTAC that degrades *MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro* protein levels in 293T cells in a time-dependent manner (DC₅₀=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882)；Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763)) .

HY-162550

Jobosic acid	SARS-CoV	Infection
Jobosic acid, a saturated fatty acid, is a selective *SARS-CoV-2* inhibitor. Jobosic acid inhibits Mpro and spike-RBD/ACE-2 interaction with IC₅₀ values of 7.5 μg/mL and 3 μg/mL, respectively. Jobosic acid shows viral entry inhibition for the omicron SARS-CoV-2 variant .

HY-136606

SARS-CoV MPro-IN-1	SARS-CoV	Infection
SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC₅₀ of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC₅₀ of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research .

HY-161789

PROTAC SARS-CoV-2 Mpro degrader-3	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC₅₀=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC₅₀ of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .

HY-162229

GRL-190-21	SARS-CoV	Infection
GRL-190-21 (compound 5e) is an inhibitor for *SARS-Cov-2-Mpro* with a K_i of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC₅₀ of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity .

HY-169256

ZINC4497834	SARS-CoV	Infection
ZINC4497834 is an inhibitor of SARS-CoV-2 major protease *Mpro*. ZINC4497834 can be used in anti-COVID19 research .

HY-169012

PSB-21110	SARS-CoV Virus Protease	Infection
PSB-21110 is an irreversible **SARS-CoV-2 Mpro** inhibitor with EC₅₀ value of 2.68 nM. PSB-21110 has antiviral activity .

HY-158763

MPI8 TG0205221	SARS-CoV Cathepsin Virus Protease	Infection
MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 *MPro* and host cell cysteine protease L (cathepsin L). This dual inhibition enhanced the overall antiviral potency and effect of MPI8. MPI8 can be used in clinical studies of COVID-19 .

HY-N144101

SARS-CoV MPro-IN-2	SARS-CoV	Infection
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-136149

Mpro inhibitor N3	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 is a potent **SARS-CoV-2 MPro** inhibitor with an EC₅₀ value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126085

(±)-Alliin 2 Publications Verification (±)-L-Alliin	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of **SARS-CoV-2 (M_pro)** .

HY-163742

SARS-CoV-2 Mpro-IN-22	Terminalia brownii Fresen. Structural Classification Combretaceae Source classification Phenols Polyphenols Plants	SARS-CoV
SARS-CoV-2 Mpro-IN-22 (compound 4), a hydrolysable tannin, is a potent **SARS-CoV-2 main protease (Mpro)** inhibitor with an IC₅₀ value of 1.2 µg/mL. SARS-CoV-2 Mpro-IN-22 does not show any significant cytotoxic activity against A549 and HUVEC cell lines .

HY-N11896A

10-Hydroxyaloin A	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	SARS-CoV
10-10-Hydroxyaloin A is potent *SARS-CoV-2* inhibitor. 10-Hydroxyaloin A exhibits significant efficacy to bind SARS-Cov-2 M_pro active site .

HY-N144101

SARS-CoV MPro-IN-2	Infection Quinones Classification of Application Fields Source classification Plants Lithospermum canescens Lehm. Naphthalene Quinones Disease Research Fields Boraginaceae	SARS-CoV
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-N12697A

Polycarpine hydrochloride	Structural Classification Alkaloids Animals Other Alkaloids Source classification	SARS-CoV Virus Protease Influenza Virus Fungal
Polycarpine hydrochloride (1a) is a broad-spectrum *Mpro* inhibitor (IC₅₀ = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC₅₀ values of 30.0 nM and 0.12 μM against **SARS-CoV-2 Mpro** and PEDV Mpro, respectively .

HY-126085R

(±)-Alliin (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Source classification Plants A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .

Cat. No.	Product Name	Chemical Structure

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

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