2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2 Mpro-IN-31

SARS-CoV-2 Mpro-IN-31 (Compound 18) is an inhibitor of SARS-CoV-2 MPro with an IC50 value of 11 nM. Additionally, SARS-CoV-2 Mpro-IN-31 effectively inhibits the enzymatic activity of the cysteine proteases cathepsin B and cathepsin L, with IC50 values of 24 nM and 1.8 nM, respectively.

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SARS-CoV-2 Mpro-IN-31 Chemical Structure

SARS-CoV-2 Mpro-IN-31 Chemical Structure

CAS No. : 870153-73-4

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SARS-CoV-2 Mpro-IN-31 Related Antibodies

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Description

SARS-CoV-2 Mpro-IN-31 (Compound 18) is an inhibitor of SARS-CoV-2 MPro with an IC50 value of 11 nM. Additionally, SARS-CoV-2 Mpro-IN-31 effectively inhibits the enzymatic activity of the cysteine proteases cathepsin B and cathepsin L, with IC50 values of 24 nM and 1.8 nM, respectively[1].

IC50 & Target

IC50: 11 nM (SARS-CoV-2 MPro)[1].
IC50: 24 nM (cathepsin B)[1].
IC50: 1.8 nM (cathepsin L)[1].
Molecular Weight

645.53

Formula

C31H34Cl2N4O7
CAS No.
SMILES

COC1=C2C=C(NC2=CC=C1)C(N[C@H](C(N[C@H](C(COC(C3=C(C=CC=C3Cl)Cl)=O)=O)C[C@@H]4CCNC4=O)=O)CC(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 Mpro-IN-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 Mpro-IN-31870153-73-4SARS-CoVSARS coronavirusnovel CoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Inhibitorinhibitorinhibit

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