SARS-CoV-2 Mpro-IN-4 

SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (M^Pro) and Cathepsin L (CatL), with IC₅₀s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 8.2 nM^[1].

MPro/CatL^[1]

SARS-CoV-2 Mpro-IN-4 (SM141) blocks SARS-CoV2 replication in A549-hACE2 cells with IC₅₀ value of 8.2 nM^[1].
SARS-CoV-2 Mpro-IN-4 (50 μM, 24 h) does not cause any notable cytotoxicity in A549-hACE2 cells^[1].
SARS-CoV-2 Mpro-IN-4 inhibits OC-43 virus mRNA expression A549 cells^[1].
SARS-CoV-2 Mpro-IN-4 inhibits SARS-CoV2 infection by inhibiting both MPro and CatL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 Mpro-IN-4 (SM141) (10 mg/kg for i.n. or 25 mg/kg for i.p.) protects K18-ACE2 mice from SARS-CoV2-induced weight loss and lethality^[1].
SARS-CoV-2 Mpro-IN-4 (3 mg/kg, i.v.) shows a short half-life of 0.8 h and high clearance of 72 mL/min/kg in in male C57Bl/6 mice^[1].
SARS-CoV-2 Mpro-IN-4 (10 mg/kg, p.o.) shows oral bioavailability of 5%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mondal S, et al. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045.  [Content Brief]