2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV MPro-IN-1

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research.

For research use only. We do not sell to patients.

SARS-CoV MPro-IN-1 Chemical Structure

SARS-CoV MPro-IN-1 Chemical Structure

CAS No. : 2413716-71-7

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Based on 1 publication(s) in Google Scholar

SARS-CoV MPro-IN-1 Related Antibodies

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Description

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

Cellular Effect
Cell Line Type Value Description References
Vero C1008 CC50
> 100 μM
Compound: 11b
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
[PMID: 32771797]
Vero C1008 CC50
> 100 μM
Compound: 22
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
[PMID: 33486200]
Vero C1008 CC50
> 100 μM
Compound: 6
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells by CCK-8 assay
[PMID: 33186044]
Vero C1008 CC50
> 100 μM
Compound: 92
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability by CellTiterGlo assay
[PMID: 34798775]
In Vivo

SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.49

Formula

C25H25FN4O4
CAS No.
SMILES

O=C(C1=CC2=CC=CC=C2N1)N[C@H](C(N[C@H](C=O)C[C@H](CCN3)C3=O)=O)CC4=CC(F)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV MPro-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV MPro-IN-12413716-71-7SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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