2. Anti-infection
  3. SARS-CoV
  4. GRL-190-21

GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a Ki of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC50 of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity.

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GRL-190-21 Chemical Structure

GRL-190-21 Chemical Structure

CAS No. : 2755957-14-1

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Description

GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a Ki of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC50 of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity[1].

Molecular Weight

513.55

Formula

C24H34F3N5O4
CAS No.
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C[C@@]2([H])C(NCCC2)=O)C#N)=O)[C@]3([H])[C@](C3(C)C)([H])C1)=O)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GRL-190-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRL-190-212755957-14-1SARS-CoVSARS coronavirusVeroE6antiviralCOVID-19protease inhibitorInhibitorinhibitorinhibit

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