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Topoisomerase I/II inhibitor 8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169509
    Topoisomerase I/II inhibitor 8

    		PARP Necroptosis Topoisomerase RIP kinase Mixed Lineage Kinase Cancer
    Topoisomerase I/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II that leads to DNA damage and PARP-1 activation, followed by the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II inhibitor 8 exhibits significant anticancer activity, effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer .
    Topoisomerase I/II inhibitor 8

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