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URAT1/GLUT9 inhibotor

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144305
    KPH2f

    		URAT1 GLUT Infection
    KPH2f is a safe, orally active, and effective dual URAT1/GLUT9 inhibitor with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively. KPH2f shows little effects on OAT1 and ABCG2 (IC50=32.14 and 26.74 μM) [1].
    KPH2f
  • HY-158056
    URAT1/GLUT9-IN-1

    		GLUT URAT1 Metabolic Disease
    URAT1/GLUT9-IN-1 (compound 29) can inhibit both uric acid transporter 1 (URAT1) (IC50=2.01 μM) and glucose transporter 9 (GLUT9) (IC50=18.21 μM). URAT1/GLUT9-IN-1 exhibits favorable pharmacokinetic properties and oral bioavailability. URAT1/GLUT9-IN-1 can be uesd for gout and hyperuricemia research [1].
    <em>URAT1</em>/<em>GLUT9</em>-IN-<em>1</em>
  • HY-143906
    URAT1 inhibitor 2

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC50 values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout [1].
    <em>URAT1</em> inhibitor 2
  • HY-163431
    URAT1 inhibitor 10

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 [1].
    <em>URAT1</em> inhibitor 10
  • HY-153706
    URAT1 inhibitor 5

    		URAT1 Cardiovascular Disease Metabolic Disease
    URAT1 inhibitor 5 (compound 16) is a potent URAT1 inhibitor. URAT1 inhibitor 5 can be used in research of hyperuricemia [1].
    <em>URAT1</em> inhibitor 5
  • HY-151432
    URAT1 inhibitor 3

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 3 is a potent, orally active, selective URAT1 inhibitor with an IC50 value of 0.8 nM. URAT1 inhibitor 3 has urate-lowering efficacy. URAT1 inhibitor 3 can be used in research of gout and hyperuricemi [1].
    <em>URAT1</em> inhibitor 3
  • HY-153970
    URAT1 inhibitor 7

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research [1].
    <em>URAT1</em> inhibitor 7
  • HY-153971
    URAT1 inhibitor 8

    		URAT1 Metabolic Disease
    URAT1 inhibitor 8 (example 247) is a potent URAT1 inhibitor, with an IC50 of 0.001 μM. URAT1 inhibitor 8 can be used for gout research [1].
    <em>URAT1</em> inhibitor 8
  • HY-114309
    URAT1 inhibitor 1

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM. URAT1 inhibitor 1 has potential to treat hyperuricemia associated with gout [1].
    <em>URAT1</em> inhibitor <em>1</em>
  • HY-160265
    URAT1 inhibitor 9

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 9 (Compound 24) is an URAT1 inhibitor that can be used in the study of gout or hyperuricemia [1].
    <em>URAT1</em> inhibitor <em>9</em>
  • HY-153969
    URAT1 inhibitor 6

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation [1].
    <em>URAT1</em> inhibitor 6
  • HY-152033
    URAT1 inhibitor 4

    		URAT1 GLUT Metabolic Disease
    URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258) [1].
    <em>URAT1</em> inhibitor 4
  • HY-153972
    URAT1&XO inhibitor 2

    		URAT1 Xanthine Oxidase Metabolic Disease Inflammation/Immunology
    URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia [1].
    <em>URAT1</em>&XO inhibitor 2
  • HY-153968
    URAT1&XO inhibitor 1

    		Xanthine Oxidase URAT1 Metabolic Disease
    URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research [1].
    <em>URAT1</em>&XO inhibitor <em>1</em>
  • HY-157306
    HC-1310

    		URAT1 Metabolic Disease
    HC-1310 URAT1 Inhibitor (Compound 83) is a potent URAT1 inhibitor and can be used for research on hyperuricemia and gout [1].
    HC-1310
  • HY-161523
    XOR/URAT1-IN-1

    		Xanthine Oxidase URAT1 Metabolic Disease
    XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model [1].
    XOR/<em>URAT1</em>-IN-<em>1</em>
  • HY-16733
    Verinurad

    RDEA3170

    		 URAT1 Metabolic Disease
    Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC50 of 25 nM [1].
    Verinurad
  • HY-15258
    Lesinurad
    2 Publications Verification

    RDEA594

    		 URAT1 Metabolic Disease
    Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad
  • HY-15258A
    Lesinurad sodium
    2 Publications Verification

    RDEA-594 sodium

    		 URAT1 Metabolic Disease
    Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad sodium
  • HY-111345
    Epaminurad

    UR-1102; URC-102

    		 URAT1 Metabolic Disease Inflammation/Immunology
    Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research [1].
    Epaminurad
  • HY-116111
    AG 370

    		PDGFR Cardiovascular Disease
    AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor [1].
    AG 370
  • HY-122957
    Huperzine C

    		Cholinesterase (ChE) Neurological Disease
    Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease [1] .
    Huperzine C
  • HY-161284
    MMP-9/10-IN-1

    		MMP Cancer
    MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC50s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) [1].
    MMP-<em>9</em>/10-IN-<em>1</em>

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